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APH1 Antibody (PA5-23466) in WB
Western blot analysis of APH1 in human lung lysate. Samples were incubated in APH1 polyclonal antibody (Product # PA5-23466) followed by a goat anti-rabbit Ig HRP secondary antibody. 1) human lung lysate using prebleed at 1:5000, 2) human lung lysate using this antibody. PicoTect ECL substrate solution was used for this test.
产品信息
PA5-23466
产品规格
种属反应
Bovine,
Dog,
Horse,
Human,
Marsupial,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A portion of amino acids 80-145 of human APH1A
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2540966
靶标信息
APH1 is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). The gamma-secretase complex is minimally composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2, although other components may exist. APH1 probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: anterior pharynx defective 1 homolog A; anterior pharynx defective 1a homolog; aph-1 homolog A, gamma secretase subunit; APH-1a; Aph-1alpha; APH1A gamma secretase subunit; Gamma-secretase subunit APH-1A; Presenilin-stabilization factor; RP4-790G17.3
基因别名: 6530402N02Rik; APH-1; APH-1A; APH1; APH1A; BOS_2946; CGI-78; PSF; RGD1311546; UNQ579/PRO1141
UniProt ID: (Human) Q96BI3
Entrez Gene ID: (Bovine) 539247, (Dog) 100855839, (Human) 51107, (Rat) 365872
metanephros development
proteolysis
membrane protein ectodomain proteolysis
Notch receptor processing
protein processing
membrane protein intracellular domain proteolysis
amyloid precursor protein catabolic process
positive regulation of catalytic activity
Notch signaling pathway
positive regulation of apoptotic process
ephrin receptor signaling pathway
