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APRIL Antibody (500-P192-1MG) in WB
Western Blot: To detect Human APRIL by Western Blot analysis APRIL Polyclonal Antibody (Product # 500-P192-1MG) can be used at a concentration of 0.1-0.2 µg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant Human APRIL is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.
产品信息
500-P192-1MG
产品规格
种属反应
Human
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
Insect cells-derived Recombinant Human APRIL
偶联物
形式
Lyophilized
浓度
0.1-1.0 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
no preservative
保存条件
-20°C
运输条件
Ambient
RRID
AB_2929756
产品详细信息
AA Sequence of recombinant protein: AVLTQKQKKQ HSVLHLVPIN ATSKDDSDVT EVMWQPALRR GRGLQAQGYG VRIQDAGVYL LYSQVLFQDV TFTMGQVVSR EGQGRQETLF RCIRSMPSHP DRAYNSCYSA GVFHLHQGDI LSVIIPRARA KLNLSPHGTF LGFVKL.
Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Human APRIL. Anti-Human APRIL-specific antibody was purified by affinity chromatography employing an immobilized Human APRIL matrix.
Sandwich ELISA: To detect Human APRIL by sandwich ELISA (using 100 µL/well antibody solution) a concentration of 0.5-2.0 µg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Human APRIL (500-P192Bt) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Human APRIL.
Western Blot: To detect Human APRIL by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 µg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant Human APRIL is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.
靶标信息
Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated APRIL (for A PRoliferation-Inducing Ligand), TALL2 (for TNF and ApoL-related Leukocyte-expressed Ligand 2), and TRDL 1a (for TNF related death ligand 1a) in human and mouse. Two receptors for APRIL were recently identified and designated TACI and BCMA. APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-kB, and induces cell death. APRIL and its close relative of BlyS and their receptors BCMA and TACI are involved in diseases of autoimmunity and cancer.
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生物信息学
蛋白别名: A proliferation-inducing ligand; APRIL; CD256; TALL-2; TNF- and APOL-related leukocyte expressed ligand 2; TNF-related death ligand 1; TRDL-1; tumor necrosis factor (ligand) superfamily, member 13; tumor necrosis factor ligand 7B; Tumor necrosis factor ligand superfamily member 13; tumor necrosis factor-like protein ZTNF2; tumor necrosis factor-related death ligand-1
基因别名: APRIL; CD256; TALL-2; TALL2; TNFSF13; TNLG7B; TRDL-1; UNQ383/PRO715; ZTNF2
UniProt ID: (Human) O75888
Entrez Gene ID: (Human) 8741
