Invitrogen

ARFRP1 Polyclonal Antibody

ARFRP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ARFRP1 Antibody (PA5-50606) in IHC (P)

Immunohistochemical analysis of ARFRP1 in paraffin embedded Human breast cancer tissue using ARFRP1 Polyclonal Antibody (Product # PA5-50606) at a 1:25 dilution.

ARFRP1 Antibody in Western Blot, Immunocytochemistry (WB, ICC/IF)

ARFRP1 Antibody in Immunocytochemistry (ICC/IF)

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产品信息

PA5-50606

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

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免疫组化（石蜡） (IHC (P))

1:25-1:100

免疫细胞化学 (ICC/IF)

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to residues near the C terminal of human ADP-ribosylation factor related protein 1

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

3.3 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 40% glycerol

内含物

0.05% sodium azide

保存条件

-20°C

运输条件

Wet ice

AB_2636059

产品详细信息

The antibody detects endogenous levels of total ARFRP1 protein.

靶标信息

The protein encoded by this gene is a membrane-associated GTP-ase which localizes to the plasma membrane and is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) proteins. This gene plays a role in membrane trafficking between the trans-Golgi network and endosomes. Alternatively spliced transcript variants encoding different isoforms have been identified.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

ARFRP1 functions upstream of ARL1 and ARL5 to coordinate recruitment of distinct tethering factors to the trans-Golgi network.

The Journal of cell biology

Ishida M,Bonifacino JS

PA5-50606 was used in Western Blotting to demonstrate that ARFRP1 is a master regulator of retrograde-carrier tethering to the TGN. The coordinated recruitment of distinct tethering factors by a bifurcated GTPase cascade may be paradigmatic of other vesicular fusion events within the cell.

Mon Nov 04 00:00:00 UTC 2019

ARFRP1 functions upstream of ARL1 and ARL5 to coordinate recruitment of distinct tethering factors to the trans-Golgi network.

The Journal of cell biology

Ishida M,Bonifacino JS

Mon Nov 04 00:00:00 UTC 2019

ARFRP1 functions upstream of ARL1 and ARL5 to coordinate recruitment of distinct tethering factors to the trans-Golgi network.

The Journal of cell biology

Ishida M,Bonifacino JS

Mon Nov 04 00:00:00 UTC 2019

生物信息学

蛋白别名: ADP-ribosylation factor related protein 1; ADP-ribosylation factor-related protein 1; ARF-related protein 1; ARP; helicase-like protein NHL; SCG10 like-protein

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基因别名: 1500006I01Rik; AI480700; ARFRP1; ARL18; ARP; ARP1

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UniProt ID: (Human) Q13795, (Mouse) Q8BXL7, (Rat) Q63055

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Entrez Gene ID: (Human) 10139, (Mouse) 76688, (Rat) 117051

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功能

GTPase activity protein binding GTP binding nucleotide binding

参与通路

small GTPase mediated signal transduction gastrulation protein localization to Golgi apparatus retrograde transport, endosome to Golgi Golgi to plasma membrane protein transport signal transduction