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ARHGEF11 Antibody (PA5-52897) in IHC
Immunohistochemical staining of ARHGEF11 in human cerebral cortex, colon, lymph node and testis using ARHGEF11 Polyclonal Antibody (Product # PA5-52897) (A) shows similar protein distribution across tissues to an independent ARHGEF11 Polyclonal Antibody (B).
产品信息
PA5-52897
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2638162
产品详细信息
Immunogen sequence: PGHTMETQAA QEPEDDLTPT PSVISVTSHP WDPGSPGQAP PGGEGDNTQL AGLEGERPEQ EDMGLCSLEH LPPRTRNSGI WESPELDRNL AEDASSTEAA GGYKVVRKAE VAGSKVVPAL P
Highest antigen sequence identity to the following orthologs: Mouse - 70%, Rat - 62%.
靶标信息
ARHGEF11 is a 1527 amino acid protein with tandem dbl homology and pleckstrin homology domains, PDZ domain, two proline rich sequences and a regulatory G protein-signaling (RGS) sequence. It acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase, but not for RAC1 or CDC42 and acts as GTPase-activating protein (GAP) for GNA12 and GNA13. It forms a complex with G proteins and stimulates neurite through retraction Rho-dependent signals. ARHGEF11 increases glutamate transport 4-fold. It interacts with EAAT4 and modulates its uptake activity and perisynaptic distribution at glutamatergic synapses. It is known to induce the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. It is ubiquitously expressed, in brain, lung, liver, kidney and skeletal muscle.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: glutamate transporter EAAT4-associated protein 48; PDZ-RhoGEF; Rho guanine exchange factor (GEF) 11; Rho guanine nucleotide exchange factor (GEF) 11; Rho guanine nucleotide exchange factor 11; RhoA-specific guanine nucleotide exchange factor; RhoGEF glutamate transport modulator; RP11-356J7.2
基因别名: ARHGEF11; GTRAP48; KIAA0380; PDZ-RHOGEF
UniProt ID: (Human) O15085
Entrez Gene ID: (Human) 9826
cytokinesis
regulation of cell growth
movement of cell or subcellular component
striated muscle contraction
G-protein coupled receptor signaling pathway
Rho protein signal transduction
establishment of cell polarity
actin cytoskeleton organization
regulation of Rho protein signal transduction
positive regulation of apoptotic process
positive regulation of GTPase activity
positive regulation of transcription, DNA-templated
regulation of small GTPase mediated signal transduction
