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ARHGEF7 Antibody (PA5-101849) in IHC (P)
Immunohistochemistry analysis of ARHGEF7 in rat brain tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with ARHGEF7 polyclonal antibody (Product # PA5-101849) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-101849
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human ARHGEF7(Accession Q14155), corresponding to amino acid residues N311-Y361.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2851281
产品详细信息
Antibody detects endogenous levels of total ARHGEF7.
靶标信息
The serine/threonine kinase, p21 activated kinase (PAK), is a downstream effector of the small GTPases Cdc42 and Rac. PAK associates with Nck, the p85 and p110 subunits of PI3-kinase and PIX (PAK-interacting exchange factor) in a focal complex. The binding of PIX is necessary for the localization and activation of PAK in the Cdc42 to Rac signaling pathway, and this binding occurs through the high affinity of the N-terminal SH3 domain of PIX for a conserved proline rich PAK sequence. PIX exists as two isoforms, alpha and beta, and both are highly expressed in heart, muscle and thymus tissues of human and rat. alphaPIX is phosphorylated via PDGF and EphB2 receptor signaling pathways or through association with PI3-kinase. The alphaPIX isoform predominantly acts as a guanine nucleotide exchange factor (GEF) on Rac, which may mediate lamellipodia formation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Beta-Pix; COOL-1; p85; p85SPR; PAK-interacting exchange factor beta; Pak3 binding protein; PIXbeta; Rho guanine nucleotide exchange factor (GEF) 7; Rho guanine nucleotide exchange factor 7; SH3 domain-containing proline-rich protein
基因别名: ARHGEF7; BETA-PIX; betaPix; betaPix-b; betaPix-c; Cool; COOL-1; COOL1; KIAA0142; mKIAA0142; Nbla10314; P50; P50BP; P85; P85COOL1; P85SPR; PAK3; PAK3BP; PIX; PIXB
UniProt ID: (Human) Q14155, (Rat) O55043, (Mouse) Q9ES28
Entrez Gene ID: (Human) 8874, (Rat) 114559, (Mouse) 54126
hematopoietic progenitor cell differentiation
Golgi organization
signal transduction
nervous system development
positive regulation of fibroblast migration
lamellipodium assembly
positive regulation of protein binding
regulation of Rho protein signal transduction
intracellular signal transduction
negative regulation of epidermal growth factor receptor signaling pathway
positive regulation of apoptotic process
positive regulation of GTPase activity
ephrin receptor signaling pathway
focal adhesion assembly
regulation of small GTPase mediated signal transduction
positive regulation of growth hormone secretion
positive regulation of substrate adhesion-dependent cell spreading
regulation of GTP binding
positive regulation of lamellipodium morphogenesis
small GTPase mediated signal transduction
astrocyte cell migration
