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产品信息
PA5-40646
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the C-terminal of human ARID4A (aa 1119-1168).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2609037
产品详细信息
Peptide sequence: NSSKCTPVKH LNVSKPQKLA RSPARISPHI KDGEKDKHRE KHPNSSPRTY
Sequence homology: Cow: 86%; Dog: 100%; Guinea Pig: 79%; Horse: 100%; Human: 100%; Mouse: 92%; Pig: 86%; Rabbit: 86%; Rat: 93%
靶标信息
ARID4A encodes a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ARID domain-containing protein 4A; AT rich interactive domain 4A (RBP1-like); AT-rich interactive domain-containing protein 4A; RBBP-1; retinoblastoma binding protein 1; Retinoblastoma-binding protein 1
基因别名: ARID4A; RBBP-1; RBBP1; RBP-1; RBP1
UniProt ID: (Human) P29374
Entrez Gene ID: (Human) 5926
regulation of gene expression by genetic imprinting
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
spermatogenesis
histone deacetylation
histone H4-K20 trimethylation
histone H3-K9 trimethylation
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
erythrocyte development
histone H3-K4 trimethylation
establishment of Sertoli cell barrier
