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产品信息
PA5-53270
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2644101
产品详细信息
Immunogen sequence: TSKYPSRDMY RESENSSFPS HRHQEKLHVN YLTSLHLQDK KSAAAEAPTD DQPTDLSLPK NPHKPTGKVL GLAHSTTGPQ ESKGISQFQV LGSQSRDCHP KACRVSPMTM SGPKKYPESL SRSGKPHHVR LENFRKME
Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 24%.
靶标信息
ARID5B encodes a member of the AT-rich interaction domain (ARID) family of DNA binding proteins. The encoded protein forms a histone H3K9Me2 demethylase complex with PHD finger protein 2 and regulates the transcription of target genes involved in adipogenesis and liver development. ARID5B also plays a role in cell growth and differentiation of B-lymphocyte progenitors, and single nucleotide polymorphisms in this gene are associated with acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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生物信息学
蛋白别名: ARID domain-containing protein 5B; AT rich interactive domain 5B (MRF1-like); AT-rich interactive domain 5B (MRF1-like); AT-rich interactive domain-containing protein 5B; Modulator recognition factor 2; modulator recognition factor 2 (MRF2); MRF-2; MRF1-like protein
基因别名: ARID5B; DESRT; MRF-2; MRF2
UniProt ID: (Human) Q14865
Entrez Gene ID: (Human) 84159
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription coactivator activity
protein binding
histone demethylase activity
transcription regulatory region DNA binding
transcription cofactor
negative regulation of transcription from RNA polymerase II promoter
kidney development
liver development
transcription, DNA-templated
male gonad development
female gonad development
post-embryonic development
fibroblast migration
histone demethylation
adrenal gland development
multicellular organism growth
fat cell differentiation
negative regulation of transcription, DNA-templated
platelet-derived growth factor receptor signaling pathway
cell development
muscle organ morphogenesis
skeletal system morphogenesis
positive regulation of sequence-specific DNA binding transcription factor activity
palate development
face morphogenesis
adipose tissue development
fat pad development
