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ARX Antibody (OSA00264W-100UL) in IHC (P)
IHC-P on paraffin sections of mouse olfactory bulb. The animal was perfused using Autoperfuser at a pressure of 110 mmHg with 300 mL 4% FA and further post fixed overnight before being processed for paraffin embedding. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers ins... View More
产品信息
OSA00264W-100UL
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ Ig
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide from aa region 2-50 of human Homeobox protein ARX conjugated to blue carrier protein was used as the antigen
偶联物
形式
Lyophilized
浓度
Conc. Not Determined
保存液
whole serum
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in rat and mouse.
Specificity of this antibody: ARX.
靶标信息
Arx contains two conserved domains, a C-peptide (or aristaless domain) and the prd-like class homeobox domain. It is a member of the group-II aristaless-related protein family whose members are expressed primarily in the central and/or peripheral nervous system. This protein is thought to be involved in CNS development. Mutations in the Arx gene cause X-linked mental retardation and epilepsy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Aristaless-related homeobox; aristaless-related homeobox, X-linked; arx {ECO:0000250|UniProtKB:Q96QS3}; cancer/testis antigen 121; Homeobox protein ARX
基因别名: ARX; CT121; EIEE1; ISSX; MRX29; MRX32; MRX33; MRX36; MRX38; MRX43; MRX54; MRX76; MRX87; MRXS1; PRTS; RGD1562672
UniProt ID: (Human) Q96QS3, (Mouse) O35085, (Rat) A6YP92
Entrez Gene ID: (Human) 170302, (Mouse) 11878, (Rat) 317268
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
chromatin binding
molecular_function
sequence-specific DNA binding
homeodomain transcription factor
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
axon guidance
positive regulation of gene expression
globus pallidus development
cerebral cortex tangential migration
embryonic olfactory bulb interneuron precursor migration
cell proliferation in forebrain
cerebral cortex GABAergic interneuron migration
regulation of cell proliferation
lipid digestion
positive regulation of organ growth
epithelial cell fate commitment
neuron migration
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
nervous system development
biological_process
olfactory bulb development
cell differentiation
forebrain development
