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产品信息
PA5-109415
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 500 to the C-terminus of human ARX (NP_620689.1).
偶联物
形式
Liquid
浓度
0.73 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2854826
产品详细信息
Immunogen sequence: LLRQPTPAVE GAVASGALAD PATAAADRRA SSIAALRLKA KEHAAQLTQL NILPGTSTGK EVC
靶标信息
Arx contains two conserved domains, a C-peptide (or aristaless domain) and the prd-like class homeobox domain. It is a member of the group-II aristaless-related protein family whose members are expressed primarily in the central and/or peripheral nervous system. This protein is thought to be involved in CNS development. Mutations in the Arx gene cause X-linked mental retardation and epilepsy.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Aristaless-related homeobox; aristaless-related homeobox, X-linked; arx {ECO:0000250|UniProtKB:Q96QS3}; cancer/testis antigen 121; Homeobox protein ARX
基因别名: ARX; CT121; EIEE1; ISSX; MRX29; MRX32; MRX33; MRX36; MRX38; MRX43; MRX54; MRX76; MRX87; MRXS1; PRTS; RGD1562672
UniProt ID: (Human) Q96QS3, (Mouse) O35085, (Rat) A6YP92
Entrez Gene ID: (Human) 170302, (Mouse) 11878, (Rat) 317268
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
chromatin binding
molecular_function
sequence-specific DNA binding
homeodomain transcription factor
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
axon guidance
positive regulation of gene expression
globus pallidus development
cerebral cortex tangential migration
embryonic olfactory bulb interneuron precursor migration
cell proliferation in forebrain
cerebral cortex GABAergic interneuron migration
regulation of cell proliferation
lipid digestion
positive regulation of organ growth
epithelial cell fate commitment
neuron migration
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
nervous system development
biological_process
olfactory bulb development
cell differentiation
forebrain development
