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ASAH3 Antibody (PA5-75603) in IHC (P)
Immunohistochemistry analysis of ASAH3 in paraffin-embedded human liver carcinoma tissue (cytoplasmic staining) and negative control (right, with PBS only). Samples were incubated with ASAH3 polyclonal antibody (Product # PA5-75603) at a dilution of 1:50, followed by goat Anti-Rabbit IgG-biotin and avidin peroxidase.
产品信息
PA5-75603
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues in Human ACER1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2719331
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 3.5.1.23; Acylsphingosine deacylase 3; alkaline CDase 1; Alkaline ceramidase 1; AlkCDase 1; CTB-180A7.3; maCER1; N-acylsphingosine amidohydrolase (alkaline ceramidase) 3; N-acylsphingosine amidohydrolase 3
基因别名: 2310024P18Rik; ACER1; AI662009; ALKCDase1; ASAH3; Cer1
UniProt ID: (Human) Q8TDN7, (Mouse) Q8R4X1
Entrez Gene ID: (Human) 125981, (Rat) 301118, (Mouse) 171168
sphingolipid metabolic process
epidermis development
response to alkaline pH
regulation of lipid metabolic process
sphingolipid biosynthetic process
cell differentiation
keratinocyte differentiation
sphingosine biosynthetic process
ceramide catabolic process
cellular response to calcium ion
lipid metabolic process
ceramide metabolic process
