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产品信息
PA5-113613
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the middle region of human ACCN1
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2884128
产品详细信息
Immunogen sequence: LLDLLGKEED EGSHDENVST CDTMPNHSET ISHTVNVPLQ TTLGTLEEIA
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Predicted homology: Cow: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%
靶标信息
ACCN1 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this protein may play a role in neurotransmission. In addition, a heteromeric association between this member and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: acid sensing (proton gated) ion channel 2; acid sensing ion channel 2; acid-sensing (proton-gated) ion channel 2; Acid-sensing ion channel 2; Amiloride-sensitive brain sodium channel; Amiloride-sensitive cation channel 1, neuronal; Amiloride-sensitive cation channel neuronal 1; ASIC2; BNC1; Brain sodium channel 1; Mammalian degenerin homolog; MDEG; neuronal amiloride-sensitive cation channel 1
基因别名: ACCN; ACCN1; ASIC2; ASIC2a; BNAC1; BNC1; hBNaC1; MDEG
UniProt ID: (Human) Q16515
Entrez Gene ID: (Human) 40
regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback
chemical synaptic transmission
central nervous system development
peripheral nervous system development
phototransduction
sensory perception of sound
response to acidic pH
regulation of gene expression
monovalent inorganic cation transport
regulation of vasoconstriction
regulation of blood coagulation
ion transmembrane transport
regulation of ion transmembrane transport
protein localization to synapse
sodium ion transmembrane transport
regulation of membrane potential
negative regulation of apoptotic process
sensory perception of sour taste
detection of mechanical stimulus involved in sensory perception
positive regulation of synapse assembly
