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ASIC3 Antibody (PA5-78825) in WB
Western blot analysis of ASIC3 in Lane 1: rat brain tissue lysate, Lane 2: rat testis tissue lysate, Lane 3: U87 cell lysate, Lane 4: NEURO cell lysate, Lane 5: SMMC cell lysate using 50 µg (reducing conditions) per well. Electrophoresis was performed on 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours and protein was transferred to a nitrocellulose membrane at 150mA for 50-90 minutes. Sample was blocked with 5% Non-fat Milk/TBS for 1.5 hours at room temperature, incubated with ASIC3 polyclonal antibody (Product... View More
产品信息
PA5-78825
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the N-terminus of human ASIC3 (56-73aa FLYQVAERVRYYREFHHQ).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide, 0.05mg thimerosal
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2745941
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
ACCN3 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. ACCN3 encodes a member that is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and ACCN1 has been observed as proton-gated channels sensitive to gadolinium.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: acid sensing (proton gated) ion channel 3; acid sensing ion channel 3; acid-sensing (proton-gated) ion channel 3; Acid-sensing ion channel 3; Amiloride-sensitive cation channel 3; amiloride-sensitive cation channel 3, testis; ASIC3; Dorsal root ASIC; DRASIC; hASIC3; hTNaC1; modulatory subunit of ASIC2a; Neuronal amiloride-sensitive cation channel 3; proton gated cation channel DRASIC; proton-gated cation channel subunit; Testis sodium channel 1
基因别名: ACCN3; ASIC3; AW742291; DRASIC; SLNAC1; TNAC1
UniProt ID: (Human) Q9UHC3, (Mouse) Q6X1Y6, (Rat) O35240
Entrez Gene ID: (Human) 9311, (Mouse) 171209, (Rat) 286920
transport
signal transduction
sensory perception
response to heat
response to acidic pH
ion transmembrane transport
sodium ion transmembrane transport
enterobactin transport
sensory perception of sour taste
detection of temperature stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of pain
detection of chemical stimulus involved in sensory perception of pain
ion transport
cation transport
sodium ion transport
response to mechanical stimulus
detection of chemical stimulus involved in sensory perception
detection of temperature stimulus involved in sensory perception
detection of mechanical stimulus involved in sensory perception
cation transmembrane transport
