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ASPM Antibody (IHC-00058) in ICC/IF
Detection of human ASPM by immunocytochemistry. Samples: NBF-fixed asynchronous HeLa cells. Antibody: Affinity purified rabbit anti-ASPM (Product # IHC-00058) used at a dilution of 1:250. Detection: goat anti-rabbit IgG (h&l) FITC (A120-101F) used at a dilution of 1:100.
Product Details
IHC-00058
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 3425 and the C-terminus (residue 3477) of human ASP (Abnormal Spindle)-like, Microcephaly Associated.
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4° C
Shipping conditions
Wet ice
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Abnormal spindle protein homolog; Abnormal spindle-like microcephaly-associated protein; asp (abnormal spindle) homolog, microcephaly associated; Asp homolog
Gene Aliases: ASP; ASPM; Calmbp1; MCPH5
UniProt ID: (Human) Q8IZT6
Entrez Gene ID: (Human) 259266
neuron migration
positive regulation of neuroblast proliferation
spindle organization
mitotic nuclear division
spermatogenesis
male gonad development
forebrain neuroblast division
cerebral cortex development
negative regulation of neuron differentiation
negative regulation of asymmetric cell division
oogenesis
developmental growth
regulation of meiotic cell cycle
spindle localization
maintenance of centrosome location
positive regulation of canonical Wnt signaling pathway
spindle assembly involved in meiosis
neuronal stem cell population maintenance
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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