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ASPM Antibody (MA5-55854) in IHC (P)
Immunohistochemistry analysis of ASPM in paraffin-embedded adrenal gland tissue. Sample was incubated with ASPM monoclonal antibody (Product # MA5-55854) at a dilution of 2.5 µg/mL (RT, 1 hour). Antigen was retrieved through addition of boiling Tris/EDTA buffer pH 9 in a pressure cooker for 3 min. Endogenous peroxidase activity was quenched by incubating the sections with 3% H2O2 for 30 min at room temperat... View More
产品信息
MA5-55854
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
K52002_11G4
抗原
Recombinant human ASPM (immunogen range is 411-720).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
产品详细信息
Sequence of this protein is as follows: CKVPLSNENS QVPQSPEDWR KSEVSPRIPE CQGSKSPKAI FEELVEMKSN YYSFIKQNNP KFSAVQDISS HSHNKQPKRR PILSATVTKR KATCTRENQT EINKPKAKRC LNSAVGEHEK VINNQKEKED FHSYLPIIDP ILSKSKSYKN EVTPSSTTAS VARKRKSDGS MEDANVRVAI TEHTEVREIK RIHFSPSEPK TSAVKKTKNV TTPISKRISN REKLNLKKKT DLSIFRTPIS KTNKRTKPII AVAQSSLTFI KPLKTDIPRH PMPFAAKNMF YDERWKEKQE QGFTWWLNFI LTPDDFTVKT
靶标信息
This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Abnormal spindle protein homolog; Abnormal spindle-like microcephaly-associated protein; asp (abnormal spindle) homolog, microcephaly associated; Asp homolog
基因别名: ASP; ASPM; Calmbp1; MCPH5
UniProt ID: (Human) Q8IZT6
Entrez Gene ID: (Human) 259266
neuron migration
positive regulation of neuroblast proliferation
spindle organization
mitotic nuclear division
spermatogenesis
male gonad development
forebrain neuroblast division
cerebral cortex development
negative regulation of neuron differentiation
negative regulation of asymmetric cell division
oogenesis
developmental growth
regulation of meiotic cell cycle
spindle localization
maintenance of centrosome location
positive regulation of canonical Wnt signaling pathway
spindle assembly involved in meiosis
neuronal stem cell population maintenance
