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ATG10 Antibody (PA5-23224) in IHC (P)
Immunohistochemical analysis of ATG10 in formalin-fixed, paraffin-embedded human brain tissue. Samples were incubated in ATG10 polyclonal antibody (Product # PA5-23224) using a dilution of 5 µg/mL. Isotype control (top left) and this antibody (bottom left, right).
产品信息
PA5-23224
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A portion of amino acids 1-50 of human APG10L
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2540749
靶标信息
ATG10 is involved in autophagy which is a process for the bulk degradation of cytosolic compartments by lysosomes/vacuoles. The formation of autophagosomes involves a dynamic rearrangement of the membrane for which two ubiquitin-like modifications (the conjugation of APG12p and the modification of a soluble form of MAP-LC3 to a membrane-bound form) are essential. APG10 is an E2-like enzyme involved in two ubiquitin-like modifications essential for autophagosome formation, ATG12 -ATG5 conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A), a homolog of yeast Apg8, to a membrane-bound form. The protein ATG10 is ubiquitously expressed and the human APG10L gene is localized on chromosome 5q14.2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: APG10-like; ATG10 autophagy related 10 homolog; autophagy related 10 homolog; autophagy-related 10; Autophagy-related protein 10; DKFZp586I0418; FLJ13954; mAPG10; Ubiquitin-like-conjugating enzyme ATG10
基因别名: 5330424L23Rik; 5430428K15Rik; Agp10; AI852123; APG10; APG10L; Apg10p; ATG10; Atg10l; PP12616
UniProt ID: (Human) Q9H0Y0, (Mouse) Q8R1P4
Entrez Gene ID: (Human) 83734, (Rat) 688555, (Mouse) 66795
ligase activity
Atg12 transferase activity
molecular_function
protein binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
