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ATG10 Antibody (PA5-96662) in IHC (P)
Immunohistochemistry analysis of ATG10 in paraffin-embedded mouse spleen. Samples were incubated with ATG10 Polyclonal antibody (Product # PA5-96662) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-96662
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 120-220 of human ATG10 (NP_1136701)
偶联物
形式
Liquid
浓度
2.13 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2808464
产品详细信息
Positive Samples: Mouse small intestine; Cellular Location: Cytoplasm
Immunogen sequence: LPLSYAKATS QDERNVP
靶标信息
ATG10 is involved in autophagy which is a process for the bulk degradation of cytosolic compartments by lysosomes/vacuoles. The formation of autophagosomes involves a dynamic rearrangement of the membrane for which two ubiquitin-like modifications (the conjugation of APG12p and the modification of a soluble form of MAP-LC3 to a membrane-bound form) are essential. APG10 is an E2-like enzyme involved in two ubiquitin-like modifications essential for autophagosome formation, ATG12 -ATG5 conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A), a homolog of yeast Apg8, to a membrane-bound form. The protein ATG10 is ubiquitously expressed and the human APG10L gene is localized on chromosome 5q14.2.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: APG10-like; ATG10 autophagy related 10 homolog; autophagy related 10 homolog; autophagy-related 10; Autophagy-related protein 10; DKFZp586I0418; FLJ13954; mAPG10; Ubiquitin-like-conjugating enzyme ATG10
基因别名: 5330424L23Rik; 5430428K15Rik; Agp10; AI852123; APG10; APG10L; Apg10p; ATG10; Atg10l; PP12616
UniProt ID: (Human) Q9H0Y0, (Mouse) Q8R1P4
Entrez Gene ID: (Human) 83734, (Rat) 688555, (Mouse) 66795
ligase activity
Atg12 transferase activity
molecular_function
protein binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
ubiquitin-protein ligase
protein modifying enzyme
