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ATG4C Antibody (PA5-106649) in ICC/IF
Immunofluorescent analysis of ATG4C in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and ATG4C polyclonal antibody (Product # PA5-106649) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
产品信息
PA5-106649
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human ATG4C(Accession Q96DT6), corresponding to amino acid residues L29-F79.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2854317
产品详细信息
Antibody detects endogenous levels of total ATG4C.
靶标信息
ATG4C is involved in autophagy, the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Highly expressed in skeletal muscle, heart, liver and testis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: APG4 (ATG4) autophagy-related homolog C; APG4 autophagy 4 homolog C; ATG4 autophagy related 4 homolog C; AUT-like 1, cysteine endopeptidase; AUT-like 3 cysteine endopeptidase; autophagin 3; Autophagin-3; autophagy related 4C, cysteine peptidase; autophagy-related 4C; Autophagy-related cysteine endopeptidase 3; Autophagy-related protein 4 homolog C; cysteine peptidase; Cysteine protease ATG4C; cysteine protease involved in autophagy; FLJ14867; HsAPG4C
基因别名: APG4-C; APG4C; ATG4C; Atg4cl; AUTL1; AUTL3
UniProt ID: (Human) Q96DT6, (Mouse) Q811C2
Entrez Gene ID: (Human) 84938, (Mouse) 242557
