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ATOH8 Antibody (PA5-95898) in WB
Western blot analysis of ATOH8 in extracts of various cell lines. Samples were incubated with ATOH8 Polyclonal antibody (Product # PA5-95898) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
产品信息
PA5-95898
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human ATOH8 (NP_1162162)
偶联物
形式
Liquid
浓度
1.35 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2807700
产品详细信息
Positive Samples: mouse brain, mouse kidney, rat brain rat kidney
Immunogen sequence: LRPRILLCAP PARPAPSAPP APPAPPESTV RPAPPTRPGE SSYSSISHVI YNNHQDSSAS PRKRPGEATA ASSEIKALQQ TRRLLANARE RTRVHTISAA F
靶标信息
Basic helix-loop-helix (bHLH) transcription factors play important roles in differentiation processes during embryonic development of vertebrates. ATOH8 (MATH6) is a tissue-restricted member of the atonal superfamily of bHLH transcription factors that exhibits 43-57% identity in the bHLH domain with other mammalian atonal paralogs including the NeuroD and Neurogenin factors. In the mouse, ATOH8 has been implicated in the specification and differentiation of neuronal cell lineages in the brain and may also participate in kidney development. Recent studies show that ATOH8 is a novel component of the pancreatic transcriptional network during embryonic development and suggest a potential role as a modulator of the differentiation program initiated by the pro-endocrine factor Neurog3. It is indispensable for early embryonic development, suggesting a more widespread function for this factor in tissue-specific differentiation processes that are dependent on class II bHLH genes.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: basic helix-loop-helix transcription factor 6; Helix-loop-helix protein mATH-6; mATH6; Okadin; Protein atonal homolog 8; Transcription factor Atoh8
基因别名: 4933425C05Rik; Ath6; Atoh8; bHLHa21; Hath6; Math6; okadin; RGD1561512
UniProt ID: (Mouse) Q99NA2
Entrez Gene ID: (Mouse) 71093, (Rat) 500200
formation of primary germ layer
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
nervous system development
cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
SMAD protein signal transduction
