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产品信息
PA5-20995
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 19 amino acid peptide near the amino terminus of human ATP11A.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11154803
产品详细信息
A suggested positive control is K562 cell lysate.
PA5-20995 can be used with blocking peptide PEP-1109.
靶标信息
ATP11A is a widely expressed integral membrane ATPase. ATP11A is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium or other molecules across membranes. While the exact molecule ATP11A transports is unknown, increased expression of ATP11A mRNA has been observed in murine leukemia cells made resistant to anti-cancer drugs such as farnesyltransferase inhibitors (FTIs). Furthermore, overexpression of ATP11A provided protection against the FTI SCH66336 while knockdown of ATP11A via siRNA made cells more sensitive to this drug. Other reports suggest that elevated levels of ATP11A mRNA may also be a predictive marker of metastasis in colorectal cancer patients.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ATPase 11A, class VI; ATPase 11A, p type; ATPase class VI type 11A; ATPase IS; ATPase, class 1, member h; ATPase, class VI, type 11A; P4-ATPase flippase complex alpha subunit ATP11A; phospholipid-translocating ATPase; Phospholipid-transporting ATPase IH; potential phospholipid-transporting ATPase IH; probable phospholipid-transporting ATPase IH; RP11-120K24.1
基因别名: 4930558F19Rik; ATP11A; Atpc1h; ATPIH; ATPIS; AU040868; Ih; KIAA1021; Ua20
UniProt ID: (Human) P98196, (Mouse) P98197
Entrez Gene ID: (Human) 23250, (Mouse) 50770, (Rat) 306600
