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ATP1A2 Antibody (PA5-101902) in IHC (P)
Immunohistochemistry analysis of ATP1A2 in human kidney cancer and adjacent normal tissues. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with ATP1A2 polyclonal antibody (Product # PA5-101902) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-101902
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human ATP1A2(Accession P50993), corresponding to amino acid residues R3-Y53.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2851334
产品详细信息
Antibody detects endogenous levels of total ATP1A2.
靶标信息
Atp1a2 encodes an Na+/K+ ATPase, which is a membrane protein that is composed of two subunits - alpha and beta. The Na+/K+ ATPase pump maintains an essential electrochemical gradient within cells through the active transport of sodium (Na+) and potassium (K+) ions. The Atp1a2 encoded protein belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These ion gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. The ATPase enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta), and the catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. The Atp1a2 gene encodes an alpha 2 subunit. Mutations in the Atp1a2 gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. Diseases associated with ATP1A2 include Alternating Hemiplegia Of Childhood and Migraine, Familial Hemiplegic, 2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATPase Na+/K+ transporting alpha 2 polypeptide; ATPase, Na+/K+ transporting, alpha 2 polypeptide; ATPase, Na+K+ transporting, alpha 2; Na(+)/K(+) ATPase alpha(+) subunit; Na(+)/K(+) ATPase alpha-2 subunit; Na+/K+ -ATPase alpha 2 subunit; Na+/K+ ATPase, alpha-A(+) catalytic polypeptide; Na+/K+ ATPase, alpha-B polypeptide; Sodium Potassium ATPase; Sodium pump subunit alpha-2; sodium-potassium ATPase catalytic subunit alpha-2; sodium/potassium-transporting ATPase alpha-2 chain; Sodium/potassium-transporting ATPase subunit alpha-2
基因别名: ATP1A2; Atpa-3; AW060654; FHM2; KIAA0778; MHP2; mKIAA0778; RATATPA2
UniProt ID: (Human) P50993, (Rat) P06686, (Mouse) Q6PIE5
Entrez Gene ID: (Human) 477, (Rat) 24212, (Mouse) 98660
sodium:potassium-exchanging ATPase activity
protein binding
ATP binding
drug binding
ATPase activity
potassium ion binding
sodium ion binding
chaperone binding
steroid hormone binding
cation-transporting ATPase activity
metal ion binding
nucleotide binding
hydrolase activity
primary active transporter
neurotransmitter uptake
regulation of the force of heart contraction
regulation of respiratory gaseous exchange by neurological system process
potassium ion transport
sodium ion transport
cellular sodium ion homeostasis
regulation of smooth muscle contraction
regulation of striated muscle contraction
regulation of blood pressure
adult locomotory behavior
visual learning
potassium ion import
establishment or maintenance of transmembrane electrochemical gradient
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
ATP hydrolysis coupled proton transport
regulation of vasoconstriction
cellular potassium ion homeostasis
ion transmembrane transport
response to nicotine
sodium ion export from cell
locomotion
negative regulation of heart contraction
negative regulation of striated muscle contraction
ATP metabolic process
negative regulation of cytosolic calcium ion concentration
regulation of glutamate uptake involved in transmission of nerve impulse
regulation of synaptic transmission, glutamatergic
relaxation of cardiac muscle
cardiac muscle contraction
cellular response to mechanical stimulus
cellular response to steroid hormone stimulus
regulation of cardiac muscle cell contraction
membrane repolarization
membrane depolarization during cardiac muscle cell action potential
cell communication by electrical coupling involved in cardiac conduction
negative regulation of calcium ion transmembrane transport
negative regulation of calcium:sodium antiporter activity
response to glycoside
regulation of cardiac conduction
potassium ion import across plasma membrane
regulation of muscle contraction
metabolic process
regulation of cardiac muscle contraction by calcium ion signaling
energy coupled proton transmembrane transport, against electrochemical gradient
transport
ion transport
