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产品信息
H00000493-M07
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
2G8
抗原
ATP2B4 (NP_001675, 1 a.a. approximately 92 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: MTNPSDRVLP ANSMAESREG DFGCTVMELR KLMELRSRDA LTQINVHYGG VQNLCSRLKT SPVEGLSGNP ADLEKRRQVF GHNVIPPKKP KT
靶标信息
The calcium pump of the plasma membrane, termed PMCA ATPase, pumps calcium from the cytosol to the extracellular space. This membrane-bound enzyme is related to a number of other ATPases including the SERCA ATPase and the sodium/K+ pump. There are four different genes encoding PMCA ATPase and studies have revealed 20 isoforms of the pump generated by alternate splicing of the primary gene products. mRNA distribution studies show that gene products 1 and 4 are transcribed in most tissues, however, products 2 and 3 are more tissue specific. Transcription of the splicing variants has also been found to be tissue specific. In the pancreas, where insulin secretion is calcium dependent, the beta cells only express the 4b isoform, however the alpha and gamma cells express both 4a and 4b isoforms. Studies have also shown that different splice variants have different affinities for calcium and calmodulin (Cat. # MA3-917 and MA3-918).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATPase, Ca++ transporting, plasma membrane 4; Matrix-remodeling-associated protein 1; Plasma membrane calcium ATPase isoform 4; Plasma membrane calcium pump isoform 4; Plasma membrane calcium-transporting ATPase 4; PMCA4; sarcolemmal calcium pump
基因别名: ATP2B2; ATP2B4; MXRA1; PMCA4; PMCA4b; PMCA4x
UniProt ID: (Human) P23634
Entrez Gene ID: (Human) 493
calcium-transporting ATPase activity
protein binding
calmodulin binding
ATP binding
sodium channel regulator activity
PDZ domain binding
protein phosphatase 2B binding
nitric-oxide synthase inhibitor activity
metal ion binding
nitric-oxide synthase binding
scaffold protein binding
primary active transporter
neural retina development
regulation of transcription from RNA polymerase II promoter
cellular calcium ion homeostasis
spermatogenesis
negative regulation of nitric oxide mediated signal transduction
hippocampus development
sperm motility
positive regulation of peptidyl-serine phosphorylation
ion transmembrane transport
negative regulation of nitric oxide biosynthetic process
negative regulation of nitric-oxide synthase activity
response to hydrostatic pressure
calcium ion transmembrane transport
negative regulation of calcineurin-NFAT signaling cascade
cellular response to epinephrine stimulus
calcium ion transmembrane import into cytosol
calcium ion import across plasma membrane
negative regulation of the force of heart contraction
negative regulation of arginine catabolic process
negative regulation of adrenergic receptor signaling pathway involved in heart process
calcium ion export
negative regulation of peptidyl-cysteine S-nitrosylation
regulation of sodium ion transmembrane transport
regulation of cell cycle G1/S phase transition
negative regulation of cardiac muscle hypertrophy in response to stress
negative regulation of citrulline biosynthetic process
regulation of cardiac conduction
positive regulation of cAMP-dependent protein kinase activity
