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产品信息
PA5-24417
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 293-322 amino acids from the N-terminal region of human ATP8A2
偶联物
形式
Liquid
浓度
0.4 mg/mL
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2541917
靶标信息
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Involved in regulation of neurite outgrowth; acting in synergy with TMEM30A. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATPase class I type 8A member 2; ATPase, aminophospholipid transporter, class I, type 8A, member 2; ATPase, aminophospholipid transporter-like, class I, type 8A, member 2; ML-1; P4-ATPase flippase complex alpha subunit ATP8A2; Phospholipid-transporting ATPase IB; probable phospholipid-transporting ATPase IB
基因别名: ATP; ATP8A2; ATPIB; CAMRQ4; IB; ML-1
UniProt ID: (Human) Q9NTI2
Entrez Gene ID: (Human) 51761
involuntary skeletal muscle contraction
axonogenesis
aging
negative regulation of cell proliferation
retina layer formation
positive regulation of neuron projection development
response to auditory stimulus
positive regulation of multicellular organism growth
inner ear morphogenesis
eating behavior
skin development
phospholipid translocation
Golgi vesicle budding
neuron development
neuromuscular process controlling posture
detection of light stimulus involved in visual perception
neurofilament cytoskeleton organization
positive regulation of phospholipid translocation
