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产品信息
MA5-31643
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
8B2H9
抗原
Purified recombinant fragment of human ATRX (AA: 2311-2492) expressed in E. coli.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2787267
产品详细信息
MA5-31643 has been tested in indirect ELISA.
靶标信息
ATRX encodes a protein that contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
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生物信息学
蛋白别名: alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae); ATP-dependent helicase ATRX; DNA dependent ATPase and helicase; helicase 2; helicase 2, X-linked; mental retardation, X-linked 52; RP5-875J14.1; Transcriptional regulator ATRX; X-linked helicase II; X-linked nuclear protein; XNP; Zinc finger helicase; Znf-HX
基因别名: ATR2; ATRX; JMS; MRX52; MRXHF1; RAD54; RAD54L; SFM1; SHS; XH2; XNP; ZNF-HX
UniProt ID: (Human) P46100
Entrez Gene ID: (Human) 546
DNA repair
DNA methylation
DNA recombination
nucleosome assembly
DNA replication-independent nucleosome assembly
chromatin remodeling
transcription, DNA-templated
regulation of transcription, DNA-templated
spermatogenesis
positive regulation of nuclear cell cycle DNA replication
covalent chromatin modification
DNA damage response, signal transduction by p53 class mediator
forebrain development
replication fork processing
positive regulation of telomere maintenance
DNA duplex unwinding
post-embryonic forelimb morphogenesis
multicellular organism growth
positive regulation of transcription from RNA polymerase II promoter
Sertoli cell development
protein localization to chromosome, telomeric region
seminiferous tubule development
cellular response to hydroxyurea
regulation of histone H3-K9 trimethylation
negative regulation of telomeric RNA transcription from RNA pol II promoter
positive regulation of telomeric RNA transcription from RNA pol II promoter
negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric
