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产品信息
PA5-33351
产品规格
种属反应
Human,
Non-human primate
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic 15 amino acid peptide from C-terminus of human AVPR2.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2550732
产品详细信息
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Baboon, Monkey (100%) Marmoset, Panda (87%) Dog (80%).
靶标信息
Avpr2 is a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin 2 and a glycopeptide, copeptin. Arginine vasopressin is a posterior pituitary hormone which is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. Avpr2 has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. Avpr2 can contract smooth muscle during parturition and lactation. Avpr2 is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. The activity of Avpr2 is mediated by G proteins which activate adenylate cyclase.
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生物信息学
蛋白别名: Antidiuretic hormone receptor; Avp2r; AVPR V2; MGC126533; MGC138386; Renal-type arginine vasopressin receptor; V2-renal V2R; V2R; Vasopressin V2 receptor
基因别名: ADHR; AVPR2; DI1; DIR; DIR3; NDI; V2R
UniProt ID: (Human) P30518
Entrez Gene ID: (Human) 554
regulation of systemic arterial blood pressure by vasopressin
positive regulation of systemic arterial blood pressure
renal water homeostasis
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
I-kappaB kinase/NF-kappaB signaling
excretion
hemostasis
positive regulation of cell proliferation
positive regulation of gene expression
telencephalon development
positive regulation of protein ubiquitination
interferon-gamma production
cellular response to hormone stimulus
response to cytokine
negative regulation of urine volume
negative regulation of renal sodium excretion
positive regulation of vasoconstriction
response to peptide
