Invitrogen

Acetyl-CoA Carboxylase Polyclonal Antibody

Acetyl-CoA Carboxylase Antibody in Immunocytochemistry (ICC/IF)

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Acetyl-CoA Carboxylase Antibody (PA5-17564) in ICC/IF

Immunofluorescent analysis of Acetyl-CoA Carboxylase in A431 cells using an Acetyl-CoA Carboxylase polyclonal antibody (Product # PA5-17564) (A) compared to an isotype control (B) showing cytoplasmic staining.

Acetyl-CoA Carboxylase Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Acetyl-CoA Carboxylase Antibody in Western Blot (WB)

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产品信息

PA5-17564

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

查看4篇已发表文章 4篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50

免疫细胞化学 (ICC/IF)

1:50

流式细胞分析 (Flow)

1:50

免疫沉淀 (IP)

1:50

产品规格

种属反应

Bovine, Human, Mouse, Non-human primate, Rat

已发表种属

Chicken, Human, Yeast

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to residues surrounding Ser523 of human acetyl CoA carboxylase alpha1

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

17 µg/mL

纯化类型

Antigen affinity chromatography

保存液

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

内含物

no preservative

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

AB_10979444

产品详细信息

It is not recommended to aliquot this antibody.

靶标信息

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

LncEDCH1 improves mitochondrial function to reduce muscle atrophy by interacting with SERCA2.

Molecular therapy. Nucleic acids

Cai B,Ma M,Zhang J,Wang Z,Kong S,Zhou Z,Lian L,Zhang J,Li J,Wang Y,Li H,Zhang X,Nie Q

PA5-17564 was used in Western Blot to determine the role of the long non-coding RNA, LncEDCH1, in the regulation of muscle atrophy and energy metabolism.

Tue Mar 08 00:00:00 UTC 2022

LncEDCH1 improves mitochondrial function to reduce muscle atrophy by interacting with SERCA2.

Molecular therapy. Nucleic acids

Cai B,Ma M,Zhang J,Wang Z,Kong S,Zhou Z,Lian L,Zhang J,Li J,Wang Y,Li H,Zhang X,Nie Q

PA5-17564 was used in Western Blot to determine the role of the long non-coding RNA, LncEDCH1, in the regulation of muscle atrophy and energy metabolism.

Tue Mar 08 00:00:00 UTC 2022

Acetyl-CoA carboxylase 1-dependent lipogenesis promotes autophagy downstream of AMPK.

The Journal of biological chemistry

Gross AS,Zimmermann A,Pendl T,Schroeder S,Schoenlechner H,Knittelfelder O,Lamplmayr L,Santiso A,Aufschnaiter A,Waltenstorfer D,Ortonobes Lara S,Stryeck S,Kast C,Ruckenstuhl C,Hofer SJ,Michelitsch B,Woelflingseder M,Müller R,Carmona-Gutierrez D,Madl T,Büttner S,Fröhlich KU,Shevchenko A,Eisenberg T

PA5-17564 was used in Western Blotting to show that in aging yeast autophagy levels highly depend on the activity of acetyl-coenzyme A carboxylase 1.

Fri Aug 09 00:00:00 UTC 2019

Acetyl-CoA carboxylase 1-dependent lipogenesis promotes autophagy downstream of AMPK.

The Journal of biological chemistry

PA5-17564 was used in Western Blotting to show that in aging yeast autophagy levels highly depend on the activity of acetyl-coenzyme A carboxylase 1.

Fri Aug 09 00:00:00 UTC 2019

Berberine (BBR) Attenuated Palmitic Acid (PA)-Induced Lipotoxicity in Human HK-2 Cells by Promoting Peroxisome Proliferator-Activated Receptor α (PPAR-α).

Medical science monitor : international medical journal of experimental and clinical research

Wu Y,Chen F,Huang X,Zhang R,Yu Z,Chen Z,Liu J

PA5-17564 was used in Western Blotting to investigate the roles of backgroun berberine in renal lipotoxicity in vitro and investigate whether PPAR-alpha was the underlying mechanism.

Mon Oct 14 00:00:00 UTC 2019

Green tea polyphenols alter lipid metabolism in the livers of broiler chickens through increased phosphorylation of AMP-activated protein kinase.

PloS one

Huang J,Zhou Y,Wan B,Wang Q,Wan X

PA5-17564 was used in Western Blotting to show that green tea polyphenols (GTPs) significantly altered the expression of lipid-metabolizing genes in the liver of chickens.