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Aconitase 1 Antibody (PA5-86044) in ICC/IF
Immunocytochemical analysis of Aconitase 1 in HepG2 cells using a Aconitase 1 Polyclonal antibody (Product # PA5-86044) as seen in green. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
产品信息
PA5-86044
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein within Human ACO1 aa 1-273
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4, with 50% Glycerol, 0.2% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2802845
靶标信息
Aconitase 1 (ACO1) also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). It plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Aconitase; aconitase 1, soluble; aconitate hydratase, cytoplasmic; Citrate hydro-lyase; cytoplasmic aconitase; Cytoplasmic aconitate hydratase; cytosplasmic aconitase; epididymis luminal protein 60; Ferritin repressor protein; IRE-BP 1; Iron regulatory protein 1; iron-responsive element binding protein 1; Iron-responsive element-binding protein 1; IRP1; OTTHUMP00000021176; OTTHUMP00000021177; OTTHUMP00000045233; soluble aconitase
基因别名: Aco-1; ACO1; Acon1; ACONS; AH; HEL60; IREB1; IREBP; IREBP1; IRP1
UniProt ID: (Human) P21399, (Rat) Q63270, (Mouse) P28271
Entrez Gene ID: (Human) 48, (Rat) 50655, (Mouse) 11428
