Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 5
Activin A Antibody (PA5-47004) in ICC/IF
Immunocytochemistry analysis of Activin A in immersion fixed SK‚BR‚3 human breast cancer cell line (left panel, positive stain) and HeLa human cervical epithelial carcinoma cell line (right panel, negative stain). Samples were incubated in Activin A polyclonal antibody (Product # PA5-47004) using a dilution of 5 µg/mL for 3 hours at room temperature followed by NorthernLights™ 557-conjugated Anti-Goat IgG S... View More
产品信息
PA5-47004
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Rat
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CHO-derived recombinant human Activin A
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2609618
产品详细信息
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
靶标信息
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Activin A mutations are associated with fibrodysplasia ossificans progressive.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: activin A; Activin beta-A chain; EDF; erythroid differentiation factor; Erythroid differentiation protein; follicle-stimulating hormone-releasing protein; FSH-releasing protein; Inhibin beta A chain; inhibin, beta A (activin A, activin AB alpha polypeptide); Inhibin, beta-1
基因别名: EDF; FRP; INHBA
UniProt ID: (Human) P08476, (Rat) P18331, (Mouse) Q04998
Entrez Gene ID: (Human) 3624, (Rat) 29200, (Mouse) 16323
G1/S transition of mitotic cell cycle
ovarian follicle development
hair follicle development
hematopoietic progenitor cell differentiation
regulation of transcription from RNA polymerase II promoter
defense response
cell cycle arrest
cell surface receptor signaling pathway
cell-cell signaling
nervous system development
negative regulation of cell proliferation
male gonad development
positive regulation of gene expression
positive regulation of pathway-restricted SMAD protein phosphorylation
striatal medium spiny neuron differentiation
cell differentiation
erythrocyte differentiation
negative regulation of cell growth
positive regulation of cellular protein metabolic process
activin receptor signaling pathway
endodermal cell differentiation
growth
negative regulation of phosphorylation
odontogenesis
response to drug
hemoglobin biosynthetic process
progesterone secretion
regulation of MAPK cascade
negative regulation of interferon-gamma biosynthetic process
negative regulation of B cell differentiation
positive regulation of erythrocyte differentiation
negative regulation of macrophage differentiation
negative regulation of cell cycle
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of follicle-stimulating hormone secretion
positive regulation of follicle-stimulating hormone secretion
negative regulation of follicle-stimulating hormone secretion
mesodermal cell differentiation
cell development
palate development
positive regulation of ovulation
SMAD protein signal transduction
eyelid development in camera-type eye
cellular response to follicle-stimulating hormone stimulus
cellular response to cholesterol
GABAergic neuron differentiation
extrinsic apoptotic signaling pathway
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
mesoderm formation
regulation of apoptotic process
negative regulation of hair follicle development
