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Activin A Antibody (702177) in ICC/IF
Immunofluorescence analysis was performed on fixed and permeabilized MDA-MB-231 cells for detection of endogenous Activin A using Anti-Activin A Recombinant Rabbit Monoclonal Antibody (Product # 702177, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for ... View More
产品信息
702177
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
21H15L7
抗原
Peptides corresponding to Human INHBA (aa 262-279, 407-423)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2633063
产品详细信息
This antibody is predicted to react with Monkey, Bovine, Sheep and Goat
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Activin A mutations are associated with fibrodysplasia ossificans progressive.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Activin beta-A chain; EDF; erythroid differentiation factor; Erythroid differentiation protein; follicle-stimulating hormone-releasing protein; FSH-releasing protein; Inhibin beta A chain; inhibin, beta A (activin A, activin AB alpha polypeptide); Inhibin, beta-1
基因别名: EDF; FRP; INHBA
UniProt ID: (Human) P08476
Entrez Gene ID: (Human) 3624
G1/S transition of mitotic cell cycle
ovarian follicle development
hair follicle development
hematopoietic progenitor cell differentiation
regulation of transcription from RNA polymerase II promoter
defense response
cell cycle arrest
cell surface receptor signaling pathway
cell-cell signaling
nervous system development
negative regulation of cell proliferation
male gonad development
positive regulation of gene expression
positive regulation of pathway-restricted SMAD protein phosphorylation
striatal medium spiny neuron differentiation
cell differentiation
erythrocyte differentiation
negative regulation of cell growth
positive regulation of cellular protein metabolic process
activin receptor signaling pathway
endodermal cell differentiation
growth
negative regulation of phosphorylation
odontogenesis
response to drug
hemoglobin biosynthetic process
progesterone secretion
regulation of MAPK cascade
negative regulation of interferon-gamma biosynthetic process
negative regulation of B cell differentiation
positive regulation of erythrocyte differentiation
negative regulation of macrophage differentiation
negative regulation of cell cycle
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of follicle-stimulating hormone secretion
positive regulation of follicle-stimulating hormone secretion
negative regulation of follicle-stimulating hormone secretion
mesodermal cell differentiation
cell development
palate development
positive regulation of ovulation
SMAD protein signal transduction
eyelid development in camera-type eye
cellular response to follicle-stimulating hormone stimulus
cellular response to cholesterol
GABAergic neuron differentiation
extrinsic apoptotic signaling pathway
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
