Invitrogen

Adenylate Cyclase 3 Polyclonal Antibody

Adenylate Cyclase 3 Antibody in Immunocytochemistry (ICC/IF)

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Adenylate Cyclase 3 Antibody (PA5-35382) in ICC/IF

Immunocytochemistry analysis of Adenylate Cyclase 3 in cultured rat neurons and glia showing strong staining of neuronal cilia using Adenylate Cyclase 3 polyclonal antibody (Product # PA5-35382) using a dilution of 1:500 (red). Axonal and dendritic staining of alpha II Spectrin monoclonal antibody (Product # MA5-18118) using a dilution of 1:500 (green) revealing the submembranous cytoskeleton and DNA (blue)... View More

Adenylate Cyclase 3 Antibody in Immunohistochemistry (IHC)

Adenylate Cyclase 3 Antibody in Western Blot (WB)

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产品信息

PA5-35382

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:2,000

查看3篇已发表文章 3篇已发表文章

免疫组化 (IHC)

1:10,000

查看5篇已发表文章 5篇已发表文章

免疫组化（冰冻） (IHC (F))

查看1篇已发表文章 1篇已发表文章

免疫细胞化学 (ICC/IF)

1:500-1:10,000

查看3篇已发表文章 3篇已发表文章

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to the C-terminal region of rat ADCY3 conjugated to KLH

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

~1.0 mg/mL

纯化类型

Affinity chromatography

保存液

PBS with 50% glycerol

内含物

5mM sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2552692

产品详细信息

This antibody contains enough material to conduct 10 mini-Western blots.

靶标信息

This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Deficiency of the minor spliceosome component U4atac snRNA secondarily results in ciliary defects in human and zebrafish.

Proceedings of the National Academy of Sciences of the United States of America

Khatri D,Putoux A,Cologne A,Kaltenbach S,Besson A,Bertiaux E,Guguin J,Fendler A,Dupont MA,Benoit-Pilven C,Qebibo L,Ahmed-Elie S,Audebert-Bellanger S,Blanc P,Rambaud T,Castelle M,Cornen G,Grotto S,Guët A,Guibaud L,Michot C,Odent S,Ruaud L,Sacaze E,Hamel V,Bordonné R,Leutenegger AL,Edery P,Burglen L,Attié-Bitach T,Mazoyer S,Delous M

PA5-35382 was used in Immunocytochemistry to indicate that alteration of cilium biogenesis is part of the physiopathological mechanisms of TALS/RFMN/LWS, secondarily to defects of minor intron splicing.

Tue Feb 28 00:00:00 UTC 2023

Agonists of prostaglandin E₂ receptors as potential first in class treatment for nephronophthisis and related ciliopathies.

Proceedings of the National Academy of Sciences of the United States of America

Garcia H,Serafin AS,Silbermann F,Porée E,Viau A,Mahaut C,Billot K,Birgy É,Garfa-Traore M,Roy S,Ceccarelli S,Mehraz M,Rodriguez PC,Deleglise B,Furio L,Jabot-Hanin F,Cagnard N,Del Nery E,Fila M,Sin-Monnot S,Antignac C,Lyonnet S,Krug P,Salomon R,Annereau JP,Benmerah A,Delous M,Briseño-Roa L,Saunier S

Published figure using Adenylate Cyclase 3 polyclonal antibody (Product # PA5-35382) in Immunocytochemistry

Tue May 03 00:00:00 UTC 2022

Primary cilia and SHH signaling impairments in human and mouse models of Parkinson's disease.

Nature communications

Schmidt S,Luecken MD,Trümbach D,Hembach S,Niedermeier KM,Wenck N,Pflügler K,Stautner C,Böttcher A,Lickert H,Ramirez-Suastegui C,Ahmad R,Ziller MJ,Fitzgerald JC,Ruf V,van de Berg WDJ,Jonker AJ,Gasser T,Winner B,Winkler J,Vogt Weisenhorn DM,Giesert F,Theis FJ,Wurst W

PA5-35382 was used in Immunocytochemistry to analyze human neural precursor cells (hNPCs) from sporadic PD (sPD) patients.

Tue Aug 16 00:00:00 UTC 2022

Primary cilia and SHH signaling impairments in human and mouse models of Parkinson's disease.

Nature communications

PA5-35382 was used in Immunocytochemistry to analyze human neural precursor cells (hNPCs) from sporadic PD (sPD) patients.

Tue Aug 16 00:00:00 UTC 2022

Palmitic acid control of ciliogenesis modulates insulin signaling in hypothalamic neurons through an autophagy-dependent mechanism.

Cell death & disease

Ávalos Y,Hernández-Cáceres MP,Lagos P,Pinto-Nuñez D,Rivera P,Burgos P,Díaz-Castro F,Joy-Immediato M,Venegas-Zamora L,Lopez-Gallardo E,Kretschmar C,Batista-Gonzalez A,Cifuentes-Araneda F,Toledo-Valenzuela L,Rodriguez-Peña M,Espinoza-Caicedo J,Perez-Leighton C,Bertocchi C,Cerda M,Troncoso R,Parra V,Budini M,Burgos PV,Criollo A,Morselli E

PA5-35382 was used in Immunohistochemistry-immunofluorescence to investigate the effect of chronic consumption of high-fat diet on cilia.

Thu Jul 28 00:00:00 UTC 2022

Palmitic acid control of ciliogenesis modulates insulin signaling in hypothalamic neurons through an autophagy-dependent mechanism.

Cell death & disease

PA5-35382 was used in Immunohistochemistry-immunofluorescence to investigate the effect of chronic consumption of high-fat diet on cilia.

Thu Jul 28 00:00:00 UTC 2022

Ciliary Type III Adenylyl Cyclase in the VMH Is Crucial for High-Fat Diet-Induced Obesity Mediated by Autophagy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Yang D,Wu X,Wang W,Zhou Y,Wang Z

PA5-35382 was used in Western Blotting to reveal a potential mechanism by which ciliary Type III adenylyl cyclase expression regulates body weight in the mouse ventromedial hypothalamus.

Sat Jan 01 00:00:00 UTC 2022

The role of ciliopathy-associated type 3 adenylyl cyclase in infanticidal behavior in virgin adult male mice.

iScience

Wu X,Yang D,Zhou Y,Li S,Wang Z

PA5-35382 was used in Western Blot to demonstrate that the main olfactory epithelium (MOE), anterior olfactory nucleus (AON), or ventromedial hypothalamus (VMH) is crucial for infanticide in adult males.

Fri Jul 15 00:00:00 UTC 2022

Chemokine CCL5 promotes robust optic nerve regeneration and mediates many of the effects of CNTF gene therapy.

Proceedings of the National Academy of Sciences of the United States of America

Xie L,Yin Y,Benowitz L

PA5-35382 was used in Immunohistochemistry to investigate whether CNTF gene therapy acts indirectly through other immune mediators.

Tue Mar 02 00:00:00 UTC 2021

Ciliary melanin-concentrating hormone receptor 1 (MCHR1) is widely distributed in the murine CNS in a sex-independent manner.

Journal of neuroscience research

Diniz GB,Battagello DS,Klein MO,Bono BSM,Ferreira JGP,Motta-Teixeira LC,Duarte JCG,Presse F,Nahon JL,Adamantidis A,Chee MJ,Sita LV,Bittencourt JC

PA5-35382 was used in Western Blotting to indicate that nonsynaptic communication plays a prominent role in the normal function of the melanin-concentrating hormonesystem.

Thu Oct 01 00:00:00 UTC 2020

Elevating Growth Factor Responsiveness and Axon Regeneration by Modulating Presynaptic Inputs.

Neuron

Zhang Y,Williams PR,Jacobi A,Wang C,Goel A,Hirano AA,Brecha NC,Kerschensteiner D,He Z

PA5-35382 was used in Immunohistochemistry to study methods to improve growth-factor responsiveness in mature neurones by over-expressing Lin28 within the retina.

Wed Jul 03 00:00:00 UTC 2019

Sequential Maturation of Olfactory Sensory Neurons in the Mature Olfactory Epithelium.

eNeuro

Liberia T,Martin-Lopez E,Meller SJ,Greer CA

Published figure using Adenylate Cyclase 3 polyclonal antibody (Product # PA5-35382) in Immunohistochemistry

Fri May 08 00:00:00 UTC 2020

生物信息学

蛋白别名: AC-III; AC3; Adenylate cyclase type 3; Adenylate cyclase type III; Adenylate cyclase, olfactive type; Adenylyl cyclase 3; adenylyl cyclase, type III; ATP pyrophosphate-lyase 3; type III adenylyl cyclase

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基因别名: AC-III; AC3; ADCY3; KIAA0511; mKIAA0511

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UniProt ID: (Human) O60266, (Rat) P21932, (Mouse) Q8VHH7

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Entrez Gene ID: (Human) 109, (Rat) 64508, (Mouse) 104111

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功能

adenylate cyclase activity calmodulin binding ATP binding calcium- and calmodulin-responsive adenylate cyclase activity metal ion binding nucleotide binding phosphorus-oxygen lyase activity protein binding lyase activity

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