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Adenylate Cyclase 5/6 Antibody (PA5-75274) in IHC (P)
Immunohistochemistry analysis of Adenylate Cyclase 5/6 in paraffin-embedded human stomach carcinoma tissue (membrane and cytoplasmic staining) and negative control (right, with PBS only). Samples were incubated with Adenylate Cyclase 5/6 polyclonal antibody (Product # PA5-75274) at a dilution of 1:50, followed by goat Anti-Rabbit IgG-biotin and avidin peroxidase.
产品信息
PA5-75274
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids 1111-1160 of Human ADCY 5
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2719002
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
Adenylate cyclase 5/6 encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: A cyclase V; A cyclase VI; AC5; AC6; ACVI; adcy5; Adenylate cyclase type 5; Adenylate cyclase type 6; Adenylate cyclase type V; Adenylate cyclase type VI; Adenylyl cyclase 5; Adenylyl cyclase 6; adenylyl cyclase type V; ATP pyrophosphate-lyase 5; ATP pyrophosphate-lyase 6; Ca(2+)-inhibitable adenylyl cyclase
基因别名: AC5; AC6; ACVI; ADCY5; ADCY6; ADCYB; AW121902; FDFM; KIAA0422; LCCS8; mKIAA0422
UniProt ID: (Human) O95622, (Human) O43306, (Rat) Q04400, (Mouse) P84309, (Rat) Q03343
Entrez Gene ID: (Human) 111, (Human) 112, (Rat) 64532, (Mouse) 224129, (Rat) 25289, (Mouse) 11512
adenylate cyclase activity
ATP binding
adenylate cyclase binding
metal ion binding
protein heterodimerization activity
receptor binding
protein binding
calcium- and calmodulin-responsive adenylate cyclase activity
protein kinase binding
nucleotide binding
lyase activity
phosphorus-oxygen lyase activity
scaffold protein binding
SNARE binding
adenosine receptor signaling pathway
cAMP biosynthetic process
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-activating dopamine receptor signaling pathway
adenylate cyclase-inhibiting dopamine receptor signaling pathway
locomotory behavior
negative regulation of neuron projection development
intracellular signal transduction
neuromuscular process controlling balance
dopamine receptor signaling pathway
cellular response to prostaglandin E stimulus
cellular response to catecholamine stimulus
maintenance of protein location in plasma membrane
renal water homeostasis
activation of adenylate cyclase activity
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
cAMP-mediated signaling
activation of protein kinase A activity
regulation of insulin secretion involved in cellular response to glucose stimulus
cellular response to glucagon stimulus
cellular response to forskolin
cyclic nucleotide biosynthetic process
negative regulation of urine volume
regulation of vasodilation
cellular response to vasopressin
