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Adiponectin Antibody (PA5-48026) in ICC/IF
Immunocytochemistry analysis of Adiponectin in immersion fixed mouse mesenchymal stem cells differentiated into adipocytes. Samples were incubated in Adiponectin polyclonal antibody (Product # PA5-48026) using a dilution of 10 µg/mL for 3 hours at room temperature followed by NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (yellow) and counterstained with DAPI (blue).
产品信息
PA5-48026
产品规格
种属反应
Rat
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Mouse myeloma cell line NS0-derived recombinant rat Adiponectin/Acrp30 Ile19-Asn244
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2576236
产品详细信息
In Western blots, approximately 45% cross-reactivity with recombinant mouse Adiponectin is observed and 35% cross-reactivity with recombinant human Adiponectin is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
Adiponectin is a protein hormone secreted exclusively by adipocytes that regulates the metabolism of lipids and glucose. Adiponectin has been shown to play a role in various physiological processes including homeostasis and obesity. Decreased levels of adiponectin are associated with obese individuals as well as insulin resistance and hyperinsulinemia (type 2 diabetes). In mice adiponectin has been shown to improve insulin signaling, thus ameliorating insulin resistance. Through activation of AMP kinase and PPAR-alpha, adiponectin can increase fatty acid transport, oxidation, and dissipation in skeletal muscle, leading to a reduction of intramyocellular lipid levels and thus improved insulin signaling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: adipocyte complement related protein of 30 kDa; adiponectin; ADPIOQ
基因别名: Acdc; Acrp30
Entrez Gene ID: (Rat) 246253
response to hypoxia
positive regulation of protein phosphorylation
glucose metabolic process
fatty acid beta-oxidation
response to nutrient
circadian rhythm
response to sucrose
response to glucose
positive regulation of signal transduction
negative regulation of platelet-derived growth factor receptor signaling pathway
positive regulation of protein kinase A signaling
negative regulation of macrophage derived foam cell differentiation
negative regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of cholesterol efflux
regulation of glucose metabolic process
response to activity
negative regulation of smooth muscle cell migration
fatty acid oxidation
negative regulation of cell migration
negative regulation of granulocyte differentiation
response to nutrient levels
negative regulation of protein autophosphorylation
positive regulation of cellular protein metabolic process
negative regulation of tumor necrosis factor production
positive regulation of interleukin-8 production
cellular response to insulin stimulus
positive regulation of myeloid cell apoptotic process
adiponectin-activated signaling pathway
negative regulation of heterotypic cell-cell adhesion
low-density lipoprotein particle clearance
response to tumor necrosis factor
cellular response to drug
response to drug
glucose homeostasis
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of MAP kinase activity
response to ethanol
negative regulation of fat cell differentiation
negative regulation of macrophage differentiation
negative regulation of low-density lipoprotein particle receptor biosynthetic process
negative regulation of gluconeogenesis
negative regulation of blood pressure
positive regulation of blood pressure
positive regulation of protein kinase activity
negative regulation of transcription, DNA-templated
positive regulation of fatty acid metabolic process
positive regulation of glucose import
negative regulation of hormone secretion
negative regulation of smooth muscle cell proliferation
negative regulation of inflammatory response
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of phagocytosis
negative regulation of synaptic transmission
brown fat cell differentiation
protein homooligomerization
response to glucocorticoid
membrane depolarization
membrane hyperpolarization
protein heterotrimerization
negative regulation of ERK1 and ERK2 cascade
response to linoleic acid
detection of oxidative stress
cellular response to cAMP
positive regulation of monocyte chemotactic protein-1 production
cellular response to epinephrine stimulus
protein localization to plasma membrane
negative regulation of intracellular protein transport
negative regulation of receptor binding
negative regulation of DNA biosynthetic process
positive regulation of glycogen (starch) synthase activity
positive regulation of metanephric glomerular visceral epithelial cell development
positive regulation of cAMP-dependent protein kinase activity
positive regulation of renal albumin absorption
negative regulation of platelet-derived growth factor receptor-alpha signaling pathway
negative regulation of metanephric mesenchymal cell migration
