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产品信息
PA5-36524
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids 70-120 of human ADM
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2553571
产品详细信息
Purity is >95% by SDS-PAGE.
靶标信息
Adrenomedullin (ADM), a vasodilator produced by most contractile cells, is characterized by persistent hypotensive activity. ADM is involved in the regulation of fluid and electrolyte homeostasis and in the maintenance of cardiovascular functioning. In hypertensive patients, the level of ADM in plasma is upregulated. Natriuresis is a common systemic manifestation of aneurysmal subarachnoid hemorrhage. ADM has strong natriuretic actions. ADM-induced natriuresis is caused by an increase in glomerular filtration rate and a decrease in distal tubular sodium reabsorption. ADM is present both in the periphery and brain, and can exert central effects such as decreasing food ingestion.
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生物信息学
蛋白别名: ADM; AMpreproadrenomedullin; preproadrenomedullin; Pro-adrenomedullin; proadrenomedullin N-20 terminal peptide; ProAM-N20
基因别名: ADM; AM; Ap; H39316; PAMP; RATAP
UniProt ID: (Human) P35318, (Rat) P43145, (Mouse) P97297
Entrez Gene ID: (Human) 133, (Rat) 25026, (Mouse) 11535
vasculogenesis
response to hypoxia
neural tube closure
response to yeast
regulation of the force of heart contraction
G-protein coupled receptor internalization
cAMP biosynthetic process
progesterone biosynthetic process
signal transduction
positive regulation of cytosolic calcium ion concentration
cell-cell signaling
heart development
female pregnancy
aging
blood circulation
androgen metabolic process
positive regulation of cell proliferation
negative regulation of cell proliferation
response to cold
response to wounding
positive regulation of heart rate
antibacterial humoral response
antifungal humoral response
cAMP-mediated signaling
positive regulation of cAMP biosynthetic process
organ regeneration
neuron projection regeneration
receptor internalization
response to lipopolysaccharide
response to insulin
odontogenesis of dentin-containing tooth
response to starvation
positive regulation of apoptotic process
negative regulation of vascular permeability
positive regulation of angiogenesis
negative regulation of vasoconstriction
positive regulation of vasodilation
hormone secretion
developmental growth
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
response to glucocorticoid
branching involved in labyrinthine layer morphogenesis
spongiotrophoblast layer development
vascular smooth muscle cell development
positive regulation of vasculogenesis
response to organic substance
calcium ion homeostasis
