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产品信息
APZ-035-200UL
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)KDQMGKGEEGYPQE, corresponding to amino acid residues 97-110 of rat alpha-synuclein, Intracellular, C-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.
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生物信息学
蛋白别名: Alpha synuclein; Alpha-synuclein; NACP; Non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor
基因别名: alphaSYN; NACP; Snca; Syn
UniProt ID: (Rat) P37377, (Mouse) O55042
Entrez Gene ID: (Rat) 29219, (Mouse) 20617
magnesium ion binding
fatty acid binding
copper ion binding
calcium ion binding
protein binding
phospholipid binding
microtubule binding
ferrous iron binding
zinc ion binding
oxidoreductase activity
kinesin binding
enzyme binding
protein domain specific binding
Hsp70 protein binding
histone binding
identical protein binding
alpha-tubulin binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
phospholipase binding
dynein binding
protein N-terminus binding
tau protein binding
beta-tubulin binding
arachidonic acid binding
phosphoprotein binding
phospholipase D inhibitor activity
metal ion binding
membrane trafficking regulatory protein
microglial cell activation
positive regulation of receptor recycling
negative regulation of protein phosphorylation
positive regulation of neurotransmitter secretion
synaptic transmission, dopaminergic
fatty acid metabolic process
neutral lipid metabolic process
phospholipid metabolic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
mitochondrial membrane organization
chemical synaptic transmission
aging
adult locomotory behavior
response to iron(II) ion
regulation of phospholipase activity
negative regulation of platelet-derived growth factor receptor signaling pathway
regulation of glutamate secretion
regulation of dopamine secretion
negative regulation of microtubule polymerization
receptor internalization
protein destabilization
response to magnesium ion
negative regulation of transporter activity
response to lipopolysaccharide
negative regulation of monooxygenase activity
positive regulation of peptidyl-serine phosphorylation
response to interferon-gamma
cellular response to oxidative stress
negative regulation of histone acetylation
regulation of locomotion
response to cocaine
dopamine biosynthetic process
dopamine metabolic process
response to drug
mitochondrial ATP synthesis coupled electron transport
regulation of macrophage activation
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of neuron apoptotic process
negative regulation of neuron apoptotic process
cellular response to fibroblast growth factor stimulus
positive regulation of endocytosis
negative regulation of exocytosis
negative regulation of dopamine metabolic process
regulation of neurotransmitter secretion
behavioral response to cocaine
regulation of neuronal synaptic plasticity
regulation of long-term neuronal synaptic plasticity
synaptic vesicle endocytosis
synaptic vesicle transport
positive regulation of synaptic transmission
synapse organization
regulation of acyl-CoA biosynthetic process
positive regulation of release of sequestered calcium ion into cytosol
negative regulation of dopamine uptake involved in synaptic transmission
negative regulation of serotonin uptake
negative regulation of norepinephrine uptake
calcium ion homeostasis
oxidation-reduction process
excitatory postsynaptic potential
long-term synaptic potentiation
positive regulation of inositol phosphate biosynthetic process
membrane organization
negative regulation of thrombin receptor signaling pathway
response to interleukin-1
cellular response to copper ion
positive regulation of protein serine/threonine kinase activity
regulation of neuron death
positive regulation of glutathione peroxidase activity
positive regulation of hydrogen peroxide catabolic process
regulation of reactive oxygen species metabolic process
