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Alsin Antibody (PA5-103595) in ICC/IF
Immunocytochemistry analysis of Alsin in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with Alsin polyclonal antibody (Product # PA5-103595) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Product Details
PA5-103595
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ALS2(Accession Q96Q42), corresponding to amino acid residues L204-S254.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2852931
Product Specific Information
Antibody detects endogenous levels of total ALS2.
Target Information
The function of this protein remains unknown.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alsin; amyotrophic lateral sclerosis 2 (juvenile); amyotrophic lateral sclerosis 2 (juvenile) homolog; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein; Amyotrophic lateral sclerosis 2 protein; Amyotrophic lateral sclerosis 2 protein homolog; amyotrophic lateral sclerosis protein 2 homolog; FLJ31851; MGC87187
Gene Aliases: 3222402C23Rik; 9430073A21Rik; ALS2; ALS2CR6; Alsin; ALSJ; IAHSP; KIAA1563; mKIAA1563; PLSJ
UniProt ID: (Human) Q9HCK9, (Mouse) Q920R0, (Rat) P0C5Y8
Entrez Gene ID: (Human) 57679, (Mouse) 74018, (Rat) 363235
guanyl-nucleotide exchange factor activity
Ran guanyl-nucleotide exchange factor activity
protein binding
Rab guanyl-nucleotide exchange factor activity
Rab GTPase binding
Rac guanyl-nucleotide exchange factor activity
protein homodimerization activity
protein serine/threonine kinase activator activity
Rho guanyl-nucleotide exchange factor activity
GTPase activator activity
identical protein binding
Rac GTPase binding
molecular_function
behavioral fear response
receptor recycling
response to oxidative stress
endosome organization
lysosomal transport
axonogenesis
neuromuscular junction development
locomotory behavior
protein localization
cell death
vesicle organization
endosomal transport
Rac protein signal transduction
regulation of Rho protein signal transduction
synaptic transmission, glutamatergic
regulation of GTPase activity
positive regulation of GTPase activity
positive regulation of protein kinase activity
neuron projection morphogenesis
protein homooligomerization
positive regulation of protein serine/threonine kinase activity
in utero embryonic development
positive regulation of Rac protein signal transduction
regulation of endosome size
Performance Guarantee
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