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Invitrogen
Androgen Receptor (ARv7 Splice Variant) Recombinant Rabbit Monoclonal Antibody (HL1239)
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Androgen Receptor (ARv7 Splice Variant) Antibody (MA5-46970) in ICC/IF
Immunofluorescent analysis of Androgen Receptor (ARv7 Splice Variant) in 22RV1, LNCap and PC-3 cells. Cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: Androgen Receptor (ARv7 Splice Variant) stained by Androgen Receptor (ARv7 Splice Variant) monoclonal antibody (Product # MA5-46970) diluted at 1:500. Red: alpha Tubulin, a cytoskeleton marker, stained by alpha Tubulin antibody [GT114] diluted... View More
产品信息
MA5-46970
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL1239
抗原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Androgen Receptor (ARv7 Splice Variant). The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2938042
产品详细信息
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
靶标信息
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AIS; androgen nuclear receptor variant 2; Androgen receptor; androgen receptor splice variant 4b; AR8; DHTR; Dihydrotestosterone receptor; HUMARA; HYSP1; KD; NR3C4; Nuclear receptor subfamily 3 group C member 4; SBMA; SMAX1; TFM
基因别名: AIS; AR; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM
UniProt ID: (Human) P10275
Entrez Gene ID: (Human) 367
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
androgen receptor activity
receptor binding
steroid binding
androgen binding
protein binding
beta-catenin binding
transcription factor binding
zinc ion binding
enzyme binding
transcription regulatory region DNA binding
protein dimerization activity
ATPase binding
transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
transport
signal transduction
cell-cell signaling
sex differentiation
cell proliferation
positive regulation of cell proliferation
negative regulation of cell proliferation
positive regulation of gene expression
cell growth
androgen receptor signaling pathway
intracellular receptor signaling pathway
prostate gland development
positive regulation of phosphorylation
positive regulation of cell differentiation
negative regulation of integrin biosynthetic process
positive regulation of integrin biosynthetic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase III promoter
positive regulation of NF-kappaB transcription factor activity
protein oligomerization
regulation of establishment of protein localization to plasma membrane
negative regulation of extrinsic apoptotic signaling pathway
