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Alomone Labs, LTD
Angiotensin II Receptor Type-2 (extracellular) Polyclonal Antibody, Atto™ 488
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Angiotensin II Receptor Type-2 (extracellular) Antibody (AAR-012-AG-50UL) in ICC/IF
Expression of Angiotensin II receptor type-2 inmouse 3T3-L1 cells - Cell surface detection of Angiotensin II receptor type-2 in intact live mouse 3T3-L1 cells with Anti-Angiotensin II Receptor Type-2 (extracellular)-ATTO Fluor-488 Antibody (#AAR-012-AG), (1:50), (green). Live view of the same field was superimposed to the fluorescent one.
产品信息
AAR-012-AG-50UL
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
DNLNATGTNESAFNC, corresponding to amino acid residues 21-35 of rat AT2 receptor, Extracellular, N-terminus
偶联物
激发/发射光谱
501/523 nm
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion that acts through at least two types of receptors, AGTR1 and AGTR2. It is an important effector controlling blood pressure and volume in the cardiovascular system and plays a major role in the development of the mammalian kidney and urinary tract. Like AGTR1, AGTR2 is a seven transmembrane G protein-coupled receptor (GPCR), but AGTR2 does not demonstrate most of the classic features of GPCR signaling. AGTR2 is involved in a wide range of activities, including the induction of neurite outgrowth and the inhibition of cellular proliferation, in addition to the known function of mediation of vasoconstriction.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Angiotensin ii at2; angiotensin II type 2 receptor; Angiotensin II type-2 receptor; angiotensin receptor 2; AT2; AT2 receptor; Type-2 angiotensin II receptor
基因别名: Agtr2; AI316812; AT2-R; AT2R; AT2R; AW107640
UniProt ID: (Rat) P35351, (Mouse) P35374
Entrez Gene ID: (Rat) 24182, (Mouse) 11609
kidney development
regulation of systemic arterial blood pressure by circulatory renin-angiotensin
renin-angiotensin regulation of aldosterone production
vasodilation by angiotensin involved in regulation of systemic arterial blood pressure
brain renin-angiotensin system
cellular sodium ion homeostasis
inflammatory response
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
positive regulation of cell proliferation
response to organonitrogen compound
negative regulation of heart rate
negative regulation of norepinephrine secretion
cerebellar cortex development
neuron differentiation
negative regulation of icosanoid secretion
positive regulation of phosphoprotein phosphatase activity
intracellular signal transduction
regulation of metanephros size
exploration behavior
positive regulation of renal sodium excretion
aldosterone secretion
angiotensin-activated signaling pathway
dopamine biosynthetic process
regulation of transcription factor import into nucleus
negative regulation of neuron apoptotic process
positive regulation of transcription, DNA-templated
positive regulation of vasodilation
negative regulation of fibroblast proliferation
positive regulation of cytokine secretion
positive regulation of nitric-oxide synthase activity
negative regulation of neurotrophin TRK receptor signaling pathway
kidney morphogenesis
cell growth involved in cardiac muscle cell development
cellular response to dexamethasone stimulus
positive regulation of metanephric glomerulus development
positive regulation of branching involved in ureteric bud morphogenesis
positive regulation of extrinsic apoptotic signaling pathway
signal transduction
G-protein coupled receptor signaling pathway
regulation of vasodilation
regulation of apoptotic process
