Osenses

Ankyrin 2 Polyclonal Antibody

1 篇参考文献

查看其他8个Ankyrin B抗体

产品信息

OSA00144W-100UL

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:2,000

-

免疫组化 (IHC)

1:1,000-1:2,000

-

其他PubMed (Misc)

-

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产品规格

种属反应

Mouse

已发表种属

Not Applicable

宿主/亚型

Rabbit / Ig

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide from internal region of mouse Ankyrin 2 (ANK2) conjugated to blue carrier protein was used as the antigen

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

Conc. Not Determined

保存液

whole serum

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

Specificity of this antibody: ANK3.

靶标信息

This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4. Multiple transcript variants encoding different isoforms have been described.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

440-kD ankyrinB: structure of the major developmentally regulated domain and selective localization in unmyelinated axons.

The Journal of cell biology

Chan W,Kordeli E,Bennett V

Wed Dec 01 00:00:00 UTC 1993

生物信息学

蛋白别名: ANK-2; ank2; Ankyrin-2; Ankyrin-B; Brain ankyrin

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基因别名: AI835472; Ank-2; Ank2; AnkB; AW491075

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UniProt ID: (Mouse) Q8C8R3

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Entrez Gene ID: (Mouse) 109676

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protein binding potassium channel regulator activity protein binding, bridging ion channel binding ATPase binding membrane traffic protein scaffold/adaptor protein

regulation of heart rate cellular calcium ion homeostasis signal transduction protein localization positive regulation of gene expression regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion regulation of cardiac muscle contraction by calcium ion signaling regulation of protein stability T-tubule organization protein localization to cell surface cellular protein localization protein localization to M-band protein localization to T-tubule regulation of apoptotic process positive regulation of potassium ion transport protein stabilization regulation of calcium ion transport positive regulation of calcium ion transport regulation of cardiac muscle contraction cardiac muscle contraction protein localization to endoplasmic reticulum protein localization to plasma membrane protein targeting to plasma membrane regulation of cardiac muscle cell contraction atrial cardiac muscle cell action potential SA node cell action potential regulation of cardiac muscle cell membrane potential atrial cardiac muscle cell to AV node cell communication SA node cell to atrial cardiac muscle cell communication regulation of heart rate by cardiac conduction regulation of AV node cell action potential regulation of SA node cell action potential regulation of atrial cardiac muscle cell action potential positive regulation of potassium ion transmembrane transporter activity regulation of calcium ion transmembrane transporter activity positive regulation of calcium ion transmembrane transporter activity regulation of cation channel activity positive regulation of cation channel activity