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APLNR (Apelin Receptor) is a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: angiotensin II receptor-like 1; Angiotensin receptor-like 1; Apelin receptor; APJ (apelin) receptor; APJ receptor; B78; G protein-coupled receptor APJ; G-protein coupled receptor APJ; G-protein coupled receptor HG11; GPCR34; HG11 orphan receptor; MSR
基因别名: AGTRL1; APJ; APJR; APLNR; HG11; msr/apj
UniProt ID: (Human) P35414, (Rat) Q9JHG3, (Mouse) Q9WV08
Entrez Gene ID: (Human) 187, (Rat) 83518, (Mouse) 23796