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产品信息
338-MSM2-P1
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
APOB/4332
抗原
Human recombinant APOB protein fragment (around aa 592-689).
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Antibody is stable for 24 months.
Positive Control: Human liver or kidney tissue. Cellular Localization: Cytoplasm. Secreted.
Specificity Comments: Post-transcriptional editing of apolipoprotein B (apoB) mRNA is regulated byAPOBEC1 (also designated human (or rat) small intestinal apolipoprotein B mRNA editing protein, HEPR or REPR) in hepatic cells to achieve a steady state proportion of edited and unedited RNA molecules. Two forms of apoB are known to circulate in the plasma of mammals. ApoB-100 is a protein primarily synthesized in the liver as a structural component of very low density lipoprotein particles. A truncated form of apoB-100, apoB-48, is synthesized in the small intestine and contains the amino-terminal 2,152 amino acids of the larger protein. This organ-specific partitioning of apoB production is the result of RNA editing of a common apoB gene.
靶标信息
Apolipoprotein B (apo B) in human plasma is a major protein of low density lipoproteins (LDL) with a molecular mass of approximately 260-500 kDa. Apolipoprotein B binds to specific receptors on cell membranes and is involved in removal of LDL and very low density lipoprotein (VLDL) cholesterol from circulation. Low-density lipoprotein (LDL) is the carrier protein for cholesterol in the blood. LDL binds to its receptor on the capillary walls and thereby mediates the uptake and clearance of cholesterol from the circulation. In atherosclerotic lesions oxidatively modified LDL is found and oxidized LDL is specifically recognized and ingested by macrophages via scavenger receptor A and CD36. Oxidized LDL may be a marker of atherosclerosis but the precise changes in oxidized LDL are not well described. MDA-oxidized LDL appear to be different from LDL oxidized by other means. Apolipoprotein B is mostly synthesized in the liver, and is a major apolipoprotein of very low density, intermediate density and low density lipoproteins (LDL) as well as being a major component of lipoprotein (a). Apolipoprotein B is a ligand for the LDL receptor and elevated levels are associated with premature atherosclerosis. Normal plasma apolipoprotein B levels are around 800mg/L. Apolipoprotein B occurs in plasma as two main isoforms, apoB-48 and apoB-100. The intestinal and the hepatic forms of Apolipoprotein B are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in the Apolipoprotein B gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective Apolipoprotein B, diseases affecting plasma cholesterol and Apolipoprotein B levels.
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生物信息学
蛋白别名: Apo B-100; Apo B100; apo-B; ApoB 100; ApoB 48; apolipo b; apolipoprotein B (including Ag(x) antigen); Apolipoprotein B 100; Apolipoprotein B 48; Apolipoprotein B-100; Apolipoprotein B100; apolipoprotein B46; apolipoprotein B47; apolipoprotein B48; apolipoprotein B49; LOX-1; mCG_129875; MGC176318; Ox-LDL receptor 1
基因别名: APOB; apoB-100; apoB-48; FLDB; LDLCQ4
UniProt ID: (Human) P04114
Entrez Gene ID: (Human) 338
retinoid metabolic process
in utero embryonic development
triglyceride mobilization
receptor-mediated endocytosis
spermatogenesis
nervous system development
cholesterol metabolic process
fertilization
response to virus
response to carbohydrate
post-embryonic development
response to selenium ion
positive regulation of gene expression
positive regulation of macrophage derived foam cell differentiation
positive regulation of lipid storage
positive regulation of cholesterol storage
triglyceride catabolic process
cholesterol transport
sperm motility
response to lipopolysaccharide
cholesterol efflux
low-density lipoprotein particle remodeling
very-low-density lipoprotein particle assembly
low-density lipoprotein particle clearance
lipoprotein metabolic process
lipoprotein biosynthetic process
lipoprotein catabolic process
cholesterol homeostasis
lipoprotein transport
cellular protein catabolic process
regulation of cholesterol biosynthetic process
artery morphogenesis
leukocyte migration
cellular response to tumor necrosis factor
cellular response to prostaglandin stimulus
