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产品信息
PA5-75688
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues in Human Apolipoprotein C1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.12
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2719416
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 100% (by SDS-PAGE).
靶标信息
Apolipoproteins are protein components of plasma lipoproteins. The apolipoprotein C gene family encodes four homologous proteins designated apoC-I to -IV, which specifically modulate the metabolism of triglyceride-rich lipoproteins. The human apoC-I gene maps to chromosome 19q13.2 and is expressed primarily in the liver where it is activated when monocytes differentiate into macrophages. The human apoC-II gene maps to chromosome 19q13.2 and encodes a 79 amino acid single chain protein that is a necessary cofactor for the activation of lipoprotein lipase, the enzyme that hydrolyzes triglycerides in plasma and transfers the fatty acids to tissues. The human apoC-III gene maps to chromosome 11q23 and encodes a protein that may delay catabolism of triglyceride-rich particles by inhibiting lipoprotein lipase and hepatic lipase. The human apoC-IV gene maps to chromosome 19q13.2 and encodes a 127 amino acid protein that is primarily expressed in the liver.
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生物信息学
蛋白别名: Apo-CI; apoC-I; Apolipoprotein C-I; apolipoprotein C-I variant I; apolipoprotein C-I variant II; Apolipoprotein C1; Liver regeneration-related protein LRRG04
基因别名: ALPCI; Apo-CI; Apo-CIB; ApoC-I; ApoC-IB; APOC1; LRRG04
UniProt ID: (Human) P02654, (Mouse) P34928, (Rat) P19939
Entrez Gene ID: (Human) 341, (Mouse) 11812, (Rat) 25292
lipid metabolic process
triglyceride metabolic process
cholesterol metabolic process
positive regulation of cholesterol esterification
negative regulation of phosphatidylcholine catabolic process
negative regulation of very-low-density lipoprotein particle clearance
regulation of cholesterol transport
negative regulation of cholesterol transport
cholesterol efflux
phospholipid efflux
plasma lipoprotein particle remodeling
high-density lipoprotein particle remodeling
very-low-density lipoprotein particle assembly
chylomicron remnant clearance
very-low-density lipoprotein particle clearance
lipoprotein metabolic process
positive regulation of catalytic activity
negative regulation of fatty acid biosynthetic process
negative regulation of lipid metabolic process
negative regulation of receptor-mediated endocytosis
negative regulation of lipid catabolic process
negative regulation of lipoprotein lipase activity
transport
lipid transport
regulation of lipid transport
