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产品信息
MA5-41565
产品规格
种属反应
Rat
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
C1
抗原
Recombinant protein Clusterin. The antigen corresponds to amino acid range 227-447 of the target protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2899047
靶标信息
Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Aging associated protein 4; apo j; Apo J a; Apo J alpha; Apo J b; Apo J beta; Apo J α; Apo J β; Apo Ja; Apo Jb; ApoJ a; ApoJ alpha; ApoJ b; ApoJ beta; ApoJ α; ApoJ β; ApoJa; ApoJb; Clusterin; Clusterin alpha / beta chain; Complement associated protein SP40; DAG; Dimeric acid glycoprotein; GP80; HGNC:2095; Ku70-binding protein 1 (KUB1); MGC24903; SGP-2; Sulfated glycoprotein 2; Sulfated glycoprotein 2 (SGP2); Testosterone repressed prostate message 2; Testosterone repressed prostate message 2 (TPRM2B); testosterone-repressed prostate message; testostrone-repressed prostate message 2; TRPM-2
基因别名: APOJ; CLI; Clu; DAG; RATTRPM2B; SGP-2; SGP2; SP-40; SP40; TRPM-2; Trpm2; TRPM2B; Trpmb
UniProt ID: (Rat) P05371
Entrez Gene ID: (Rat) 24854
cell morphogenesis
microglial cell activation
response to oxidative stress
spermatogenesis
aging
positive regulation of cell proliferation
response to light stimulus
response to wounding
response to virus
protein import
endocrine pancreas development
central nervous system myelin maintenance
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of protein homooligomerization
positive regulation of tumor necrosis factor production
response to potassium ion
positive regulation of apoptotic process
negative regulation of apoptotic process
estrous cycle
positive regulation of nitric oxide biosynthetic process
positive regulation of cell differentiation
neuron projection morphogenesis
protein stabilization
positive regulation of NF-kappaB transcription factor activity
chaperone-mediated protein complex assembly
response to misfolded protein
chaperone-mediated protein folding
microglial cell proliferation
cellular response to growth factor stimulus
intrinsic apoptotic signaling pathway
regulation of beta-amyloid clearance
regulation of neuron death
positive regulation of neuron death
positive regulation of beta-amyloid formation
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of beta-amyloid formation
regulation of neuronal signal transduction
positive regulation of tau-protein kinase activity
positive regulation of neurofibrillary tangle assembly
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of intrinsic apoptotic signaling pathway
