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产品信息
PA5-78808
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the C-terminus of human Aquaporin 2 (245-260aa DWEEREVRRRQSVELH).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide, 0.05mg thimerosal
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2745924
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
Aquaporin 2 (AQP2) is a hormonally regulated water channel located in the renal collecting duct. Mutations in the AQP2 gene cause hereditary nephrogenic diabetes insipidus in humans. A vasopressin induced cAMP increase results in the phosphorylation of AQP2 at serine-256 and its translocation from the intracellular vesicles to the apical membrane of principal cells. Recently, serine-261 has been identified as a novel phosphorylation site on AQP2 and levels of phosphorylated S261 have been shown to decrease with vasopressin treatment suggesting its involvement in vasopressin-dependent AQP2 trafficking.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ADH water channel; AQP 2; AQP CD; AQP-2; AQP-CD; AQPCD; aquaporin 2 (collecting duct); Aquaporin CD; Aquaporin-2; Aquaporin-CD; Aquaporin2; Aquaporine 2; Collecting duct water channel protein; MGC34501; Water channel protein for renal collecting duct; water-channel aquaporin 2; WCH CD; WCH-CD; WCHCD
基因别名: AQP-2; AQP-CD; AQP2; aquaporin-2; cph; jpk; WCH-CD
UniProt ID: (Human) P41181, (Mouse) P56402, (Rat) P34080
Entrez Gene ID: (Human) 359, (Mouse) 11827, (Rat) 25386
renal water homeostasis
renal water transport
water transport
excretion
cellular water homeostasis
glycerol transport
ion transmembrane transport
cellular response to water deprivation
cellular response to copper ion
cellular response to mercury ion
metanephric collecting duct development
transport
cell volume homeostasis
apoptotic process
actin filament depolymerization
carbohydrate transmembrane transport
positive regulation of calcium ion transport
transmembrane transport
hyperosmotic response
female pregnancy
aging
response to water deprivation
response to salt stress
response to hormone
response to lithium ion
water homeostasis
response to lipopolysaccharide
response to glucagon
response to starvation
response to calcium ion
