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Argonaute 3 Antibody (MA5-42741) in IHC (P)
Immunohistochemistry analysis of Argonaute 3 in paraffin-embedded human lung cancer. Samples were incubated with Argonaute 3 Monoclonal antibody (Product # MA5-42741) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
产品信息
MA5-42741
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
8E0O6
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 721-860 of human eIF2C3 (Q9H9G7).
偶联物
形式
Liquid
浓度
2 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2911882
产品详细信息
Positive test controls include: HeLa, C2C12, U-87MG, Mouse lung, Mouse brain, Rat lung.
Immunogen sequence: RTERVGRSGN IPAGTTVDTD ITHPYEFDFY LCSHAGIQGT SRPSHYHVLW DDNCFTADEL QLLTYQLCHT YVRCTRSVSI PAPAYYAHLV AFRARYHLVD KEHDSAEGSH VSGQSNGRDP QALAKAVQIH QDTLRTMYFA
靶标信息
AGO3 (protein argonaute-3) is required to RNA-mediated gene silencing (RNAi). It binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. AGO3 is proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: argonaute 3; Argonaute RISC catalytic component 3; Argonaute3; eIF-2C 3; eIF2C 3; Eukaryotic translation initiation factor 2C 3; eukaryotic translation initiation factor 2C, 3; hAgo3; mAgo3; Piwi/Argonaute family protein meIF2C3; Protein argonaute-3
基因别名: AGO3; AW048688; C130014L07Rik; EIF2C3
UniProt ID: (Human) Q9H9G7, (Mouse) Q8CJF9
Entrez Gene ID: (Human) 192669, (Mouse) 214150, (Rat) 313593
mRNA catabolic process
Wnt signaling pathway, calcium modulating pathway
RNA secondary structure unwinding
pre-miRNA processing
posttranscriptional gene silencing by RNA
production of miRNAs involved in gene silencing by miRNA
miRNA mediated inhibition of translation
mRNA cleavage involved in gene silencing by miRNA
miRNA loading onto RISC involved in gene silencing by miRNA
phosphatidylinositol-mediated signaling
regulation of stem cell proliferation
mRNA cleavage involved in gene silencing by siRNA
regulation of translation
gene silencing by RNA
biological_process
