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Rockland
Aubergine/Sting Polyclonal Antibody
Product Details
600-401-947
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fruit fly
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of Drosophila melanogaster Aubergine/Sting protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
0.02M potassium phosphate, pH 7.2, with 0.15M NaCl
Contains
0.01% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Anti-Aubergine affinity-purified antibody is directed against Drosophila Aubergine protein. A BLAST analysis was used to suggest limited cross reactivity with Aubergine protein from other sources.
Target Information
Aubergine (Sting) is a Drosophila protein involved in germ-line development and RNA interference. Drosophila melanogaster has a robust and efficient innate immune system, which reacts to infections ranging from bacteria to fungi and, as discovered recently, viruses as well. The known Drosophila immune responses rely on humoral and cellular activities, similar to those found in the innate immune system of other animals. Recently, RNAi or 'RNA silencing' has arisen as a possible means by which Drosophila can react to specific pathogens, transposons and retroviral elements, in a fashion similar to that of a traditional mammalian adaptive immune system instead of in a more generalized and genome encoded innate immune-based response. RNAi is a highly conserved regulation and defense mechanism, which suppresses gene expression via targeted RNA degradation directed by either exogenous dsRNA (cleaved into siRNAs) or endogenous miRNAs. In plants, RNAi has been found to act as an antiviral immune response system. In Drosophila multiple core RNAi pathway genes have been reported, including piwi, vasa intronic gene (vig), aubergine (aub), armitage (armi), Rm62, r2d2 and Argonaute2 (AGO2).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Aub; aub-PA; aub-PC; CG6137-PA; CG6137-PC; Protein aubergine; Protein sting; stellate-interacting gene
Gene Aliases: AUB; CG6137; Dmel\CG6137; Dmel_CG6137; ms(2)32D; sti; sting
UniProt ID: (Fruit fly) O76922
Entrez Gene ID: (Fruit fly) 34524
mRNA splicing, via spliceosome
oocyte maturation
chromatin silencing
mitotic chromosome condensation
pole cell formation
regulation of pole plasm oskar mRNA localization
pole plasm protein localization
negative regulation of transposition
RNA interference
targeting of mRNA for destruction involved in RNA interference
karyosome formation
gene silencing by RNA
segmentation
positive regulation of innate immune response
regulation of oskar mRNA translation
positive regulation of oskar mRNA translation
maintenance of pole plasm mRNA location
dorsal appendage formation
oogenesis
defense response to Gram-negative bacterium
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
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