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产品信息
AURKA-BIOTIN
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide taken within amino acid region 350-397 on human Aurora Kinase A protein.
偶联物
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
AURKA (Aurora A) is a serine/threonine kinase that regulates mitosis by association in vivo with centrosomes. Overexpression of AURKA is observed in many types of cancer. Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment. Tissue specificity: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ARK-1; AURAK; Aurora 2; aurora A; Aurora A Kinase; aurora family kinase 1; Aurora kinase A; aurora-A; aurora-related kinase 1; aurora/IP; Aurora/IPL1-related kinase 1; AURORA2; EC 2.7.11.1; hARK1; Ipl1- and aurora-related kinase 1; IPL1-related kinase; MGC34538; OTTHUMP00000031341; OTTHUMP00000166072; ratAurA; RP5-1167H4.6; serine/threonine kinase 6; serine/threonine protein kinase 6; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A; Serine/threonine-protein kinase Ayk1
基因别名: Aik; AIRK1; ARK-1; Ark1; AU019385; Aura; Aurka; Aurora-A; AW539821; Ayk1; Btak; IAK; IAK1; Stk15; Stk6
UniProt ID: (Mouse) P97477
Entrez Gene ID: (Mouse) 20878, (Rat) 261730
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein kinase binding
ubiquitin protein ligase binding
histone serine kinase activity
non-receptor serine/threonine protein kinase
meiotic spindle organization
microtubule cytoskeleton organization
mitotic cell cycle
protein phosphorylation
cell cycle
spindle organization
mitotic spindle organization
spindle assembly involved in female meiosis I
mitotic nuclear division
mitotic centrosome separation
meiotic nuclear division
anterior/posterior axis specification
phosphorylation
cell projection organization
regulation of protein stability
negative regulation of protein binding
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of cytokinesis
histone-serine phosphorylation
negative regulation of apoptotic process
centrosome organization
cell division
centrosome localization
protein localization to centrosome
negative regulation of spindle checkpoint
positive regulation of oocyte maturation
neuron projection extension
response to estradiol
