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Aurora A/B Antibody (MA5-47418) in ICC/IF
Immunofluorescent analysis of Aurora A in HeLa cell culture. Samples were stained with Aurora A monoclonal antibody (Product # MA5-47418) in green. Costained with chicken pAb to vimentin in red. The blue is DAPI staining of nuclear DNA. The aurora A antibody stains spindle poles and mitotic spindles at anaphase and concentrates on the midbody between the two daughter cells during telophase.
产品信息
MA5-47418
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
3H1
抗原
Full length recombinant human Aurora A protein expressed in and purified from E. coli.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS with 50% glycerol
内含物
5mM sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2942400
靶标信息
The Aurora gene, a serine-threonine kinase, orginally discovered in Drosophila, has been found to be responsible for a chromosomal segregation defect. The mammalian homologues of Drosophila Aurora have been termed ARK1 (Aurora-related kinase 1) and ARK2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AIM-1; ARK-1; ARK-2; Aurora 1; Aurora 2; aurora A; aurora B; aurora family kinase 1; Aurora kinase A; Aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; Aurora- and IPL1-like midbody-associated protein 1; aurora-1; aurora-A; aurora-B; aurora-related kinase 1; aurora-related kinase 2; aurora/IPL1-like kinase; Aurora/IPL1-related kinase 1; Aurora/IPL1-related kinase 2; Breast tumor-amplified kinase; Ipl1- and aurora-related kinase 1; protein phosphatase 1, regulatory subunit 47; protein phosphatase 1, regulatory subunit 48; ratAurA; serine/threonine kinase 12; serine/threonine kinase 5; serine/threonine kinase 6; serine/threonine protein kinase 15; serine/threonine protein kinase 6; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A; Serine/threonine-protein kinase aurora-B; Serine/threonine-protein kinase Ayk1; STK-1
基因别名: AIK; AIK2; AIM-1; AIM1; AIRK1; AIRK2; AL022959; ARK-1; ARK-2; ARK1; ARK2; AU019385; AURA; AurB; AURKA; AURKB; aurkb-sv1; aurkb-sv2; Aurora-A; AW539821; AYK1; BTAK; IAK; IAK1; IPL1; PPP1R47; PPP1R48; STK-1; STK1; STK12; STK15; STK5; STK6; STK7
UniProt ID: (Human) O60445, (Human) Q96GD4, (Mouse) P97477, (Mouse) O70126, (Rat) O55099
Entrez Gene ID: (Human) 6790, (Human) 9212, (Mouse) 20878, (Rat) 261730, (Mouse) 20877, (Rat) 114592
protein kinase activity
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein binding
ATP binding
protein kinase binding
ubiquitin protein ligase binding
histone serine kinase activity
metal ion binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
G2/M transition of mitotic cell cycle
meiotic spindle organization
protein phosphorylation
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
spindle organization
mitotic spindle organization
spindle assembly involved in female meiosis I
mitotic nuclear division
mitotic centrosome separation
anterior/posterior axis specification
anaphase-promoting complex-dependent catabolic process
regulation of protein stability
negative regulation of protein binding
response to estradiol
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of cytokinesis
histone-serine phosphorylation
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of apoptotic process
positive regulation of mitotic nuclear division
regulation of centrosome cycle
protein autophosphorylation
cell division
centrosome localization
protein localization to centrosome
positive regulation of oocyte maturation
regulation of signal transduction by p53 class mediator
neuron projection extension
negative regulation of transcription from RNA polymerase II promoter
negative regulation of B cell apoptotic process
sister chromatid cohesion
aging
cell proliferation
attachment of spindle microtubules to kinetochore
abscission
histone modification
protein sumoylation
spindle checkpoint
positive regulation of telomere maintenance via telomerase
negative regulation of cytokinesis
positive regulation of cytokinesis
protein localization to kinetochore
cellular response to UV
cleavage furrow formation
histone H3-S28 phosphorylation
mitotic spindle midzone assembly
positive regulation of telomerase activity
regulation of chromosome segregation
positive regulation of telomere capping
microtubule cytoskeleton organization
mitotic cell cycle
cell cycle
meiotic nuclear division
phosphorylation
cell projection organization
centrosome organization
negative regulation of spindle checkpoint
