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Aurora C Antibody (PA5-118973) in IHC (P)
Immunohistochemistry analysis of Aurora C in paraffin-embedded Mouse Cerebrum tissue. Samples were incubated with polyclonal antibody (Product # PA5-118973) at a dilution of 20 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG using a dilution of 2 µg/mL.
产品信息
PA5-118973
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein Aurora Kinase C. The antigen corresponds to amino acid range 5-237 of the target protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2903473
靶标信息
AURKC (Aurora C) is a chromosomal passenger protein that forms complexes with AURKB (Aurora B) and inner centromere proteins, playing a role in organizing microtubules in relation to centrosome/spindle function during mitosis. It is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Studies on the temporal expression pattern and subcellular localization of Aurora kinases in mitotic cells suggest an association with mitotic structure. Aurora kinase functional influences span from G2 phase to cytokinesis and may be involved in key cell cycle events such as centrosome duplication, chromosome bi-orientation and segregation, cleavage furrow positioning, and ingression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ARK-3; Aurora 3; aurora B; Aurora kinase C; aurora-related kinase 3; Aurora/IPL1-related kinase 3; Aurora/IPL1/Eg2 protein 1; serine/threonine kinase 13 (aurora/IPL-like); Serine/threonine-protein kinase 13; Serine/threonine-protein kinase aurora-C
基因别名: AIE1; AIK3; Airk3; ARK-3; Ark3; Aurkc; IAK3; Stk13
UniProt ID: (Mouse) O88445
Entrez Gene ID: (Mouse) 20871
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
histone serine kinase activity
non-receptor serine/threonine protein kinase
