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BAG3 Antibody (PA5-120306) in IHC (P)
Immunohistochemistry analysis of BAG3 in paraffin-embedded mouse heart. Samples were incubated with BAG3 Polyclonal antibody (Product # PA5-120306) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-120306
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 380-575 of human BAG3 (NP_004272.2).
偶联物
形式
Liquid
浓度
1.76 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2913878
产品详细信息
Positive test controls include: A-549, HeLa, HepG2, Mouse brain, Mouse testis.
Immunogen sequence: PSAVPSSPKS VATEERAAPS TAPAEATPPK PGEAEAPPKH PGVLKVEAIL EKVQGLEQAV DNFEGKKTDK KYLMIEEYLT KELLALDSVD PEGRADVRQA RRDGVRKVQT ILEKLEQKAI DVPGQVQVYE LQPSNLEADQ PLQAIMEMGA VAADKGKKNA GNAEDPHTET QQPEATAAAT SNPSSMTDTP GNPAAP
靶标信息
BAG3 are among BAG proteins that compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BAG family molecular chaperone regulator 3; BAG-3; Bcl-2-associated athanogene 3; Bcl-2-binding protein Bis; Bcl-2-interacting death suppressor; BCL2-associated athanogene 3; BCL2-binding athanogene 3; DKFZp434E0610; Docking protein CAIR-1; MGC104307
基因别名: AA407278; BAG-3; BAG3; BIS; CAIR-1; MFM6; mg638; MNCb-2243
UniProt ID: (Human) O95817, (Mouse) Q9JLV1
Entrez Gene ID: (Human) 9531, (Mouse) 29810, (Rat) 293524
apoptotic process
extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of striated muscle cell apoptotic process
protein stabilization
cellular response to mechanical stimulus
extrinsic apoptotic signaling pathway in absence of ligand
brain development
spinal cord development
protein folding
negative regulation of apoptotic process
regulation of catalytic activity
cell-cell adhesion
regulation of cellular response to heat
