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产品信息
PA5-22026
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 1 and 266 of BAIAP2L1 (Uniprot ID#Q9UHR4)
偶联物
形式
Liquid
浓度
0.55 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_11153435
产品详细信息
Recommended positive controls: 293T, A431, HeLa, HepG2.
Predicted reactivity: Mouse (94%), Rat (94%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: BAI1-associated protein 2-like 1; BAI1-associated protein 2-like protein 1; BAR/IMD domain-containing adapter protein 2-like 1; Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1; Insulin receptor tyrosine kinase substrate
基因别名: BAIAP2L1; IRTKS
UniProt ID: (Human) Q9UHR4
Entrez Gene ID: (Human) 55971
plasma membrane organization
insulin receptor signaling pathway
response to bacterium
positive regulation of actin filament polymerization
regulation of insulin receptor signaling pathway
actin filament bundle assembly
actin crosslink formation
cell-cell adhesion
positive regulation of actin cytoskeleton reorganization
