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产品信息
PA5-56173
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.05 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2638463
产品详细信息
Immunogen sequence: EEKRRFCFLV DKHCGFANHI HYYHLQSAEL LNSKLPRWQE TCVDAIKVPE KIMNMIEEIK TPASTPVSGT PQASPMI
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 90%.
靶标信息
This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation.
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生物信息学
蛋白别名: BAI1-associated protein 2-like 1; BAI1-associated protein 2-like protein 1; BAR/IMD domain-containing adapter protein 2-like 1; Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1; Insulin receptor tyrosine kinase substrate
基因别名: BAIAP2L1; IRTKS; RGD1308452
UniProt ID: (Human) Q9UHR4, (Rat) Q3KR97
Entrez Gene ID: (Human) 55971, (Rat) 304282
plasma membrane organization
insulin receptor signaling pathway
response to bacterium
positive regulation of actin filament polymerization
regulation of insulin receptor signaling pathway
actin filament bundle assembly
actin crosslink formation
cell-cell adhesion
positive regulation of actin cytoskeleton reorganization
biological_process
